Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2702351..2703270 Replicon chromosome
Accession NZ_CP043501
Organism Bacillus paralicheniformis strain A4-3

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7TYV7
Locus tag FLQ07_RS13950 Protein ID WP_023856735.1
Coordinates 2702524..2703270 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7TM13
Locus tag FLQ07_RS13945 Protein ID WP_023856734.1
Coordinates 2702351..2702524 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLQ07_RS13925 2697776..2698873 + 1098 WP_025811596.1 mannonate dehydratase -
FLQ07_RS13930 2698849..2699697 + 849 WP_023856787.1 SDR family oxidoreductase -
FLQ07_RS13935 2699723..2700736 + 1014 WP_079289562.1 zinc-binding alcohol dehydrogenase family protein -
FLQ07_RS13940 2700788..2702059 + 1272 WP_096748019.1 MFS transporter -
FLQ07_RS13945 2702351..2702524 - 174 WP_023856734.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
FLQ07_RS13950 2702524..2703270 - 747 WP_023856735.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
FLQ07_RS13955 2703381..2704379 - 999 WP_075212749.1 inorganic phosphate transporter -
FLQ07_RS13960 2704392..2705009 - 618 WP_023856737.1 DUF47 domain-containing protein -
FLQ07_RS13965 2705342..2707099 + 1758 WP_025811589.1 gamma-glutamyltransferase -
FLQ07_RS13970 2707234..2707878 + 645 WP_003180888.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29421.87 Da        Isoelectric Point: 4.6015

>T138898 WP_023856735.1 NZ_CP043501:c2703270-2702524 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Download         Length: 747 bp

>T138898 NZ_CP058259:510632-510886 [Actinomyces sp. oral taxon 169]
ATGCGTCTCGTATGGGACCCGTATGCTTGGGAGGACTATACGCACTGGCAGAAGGCGGACCGCCGGATCCTCAAACGGGT
CAACACGCTCATCGATGCGGCCCTTCGCGATCCCTTCGGAGGTATCGGTAAACCTGGGCGGCTCAAGTACGGCGCCTCGG
GTGCGTGGTCGCGAAGGATCACTGACGAGCATCGCCTCGTGTACCTCGTTGCTGGTGATGACCTGGTGATTCTCCAAGTT
CGCTACCACTACTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.8356

>AT138898 WP_023856734.1 NZ_CP043501:c2702524-2702351 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp

>AT138898 NZ_CP058259:510381-510632 [Actinomyces sp. oral taxon 169]
ATGTCTATCAGTGCAAGCGAGGCGCGCAAGACGTTGTACCCGCTCATCGAGCGAGTCAACGCCGATCATGACGCCGTTGA
GATTGTTTCACGTAAGGGCAGTGCTGTTCTTATGCCCGCCGACGAGTACGCTGCTTGGCAGGAGACCGCCTACCTGTTCC
GATCACCTGAGAACGCGCGACGCCTTCTTGATGCGTATGACCGGGCTCGTGCGGGCCACACGGAGATGCATGACCTCGAC
CAGGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7TYV7

Antitoxin

Source ID Structure
AlphaFold DB A0A6I7TM13

References