138897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1784624..1785260 Replicon chromosome
Accession NZ_CP043501
Organism Bacillus paralicheniformis strain A4-3

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag FLQ07_RS09025 Protein ID WP_003179128.1
Coordinates 1784910..1785260 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag FLQ07_RS09020 Protein ID WP_006638778.1
Coordinates 1784624..1784905 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLQ07_RS09000 1779735..1781219 + 1485 WP_039073238.1 PH domain-containing protein -
FLQ07_RS09005 1781216..1781815 - 600 WP_048349919.1 rhomboid family intramembrane serine protease -
FLQ07_RS09010 1782159..1783118 + 960 WP_164468292.1 outer membrane lipoprotein carrier protein LolA -
FLQ07_RS09015 1783343..1784512 + 1170 WP_048349920.1 alanine racemase -
FLQ07_RS09020 1784624..1784905 + 282 WP_006638778.1 hypothetical protein Antitoxin
FLQ07_RS09025 1784910..1785260 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FLQ07_RS09030 1785378..1786205 + 828 WP_023857863.1 RsbT co-antagonist protein RsbRA -
FLQ07_RS09035 1786209..1786574 + 366 WP_031305225.1 STAS domain-containing protein -
FLQ07_RS09040 1786577..1786978 + 402 WP_023857861.1 anti-sigma regulatory factor -
FLQ07_RS09045 1786989..1787996 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
FLQ07_RS09050 1788055..1788381 + 327 WP_020450262.1 anti-sigma factor antagonist -
FLQ07_RS09055 1788381..1788863 + 483 WP_020450263.1 anti-sigma B factor RsbW -
FLQ07_RS09060 1788829..1789620 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
FLQ07_RS09065 1789617..1790216 + 600 WP_035337155.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T138897 WP_003179128.1 NZ_CP043501:1784910-1785260 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T138897 NZ_CP058259:510381-510632 [Actinomyces sp. oral taxon 169]
ATGTCTATCAGTGCAAGCGAGGCGCGCAAGACGTTGTACCCGCTCATCGAGCGAGTCAACGCCGATCATGACGCCGTTGA
GATTGTTTCACGTAAGGGCAGTGCTGTTCTTATGCCCGCCGACGAGTACGCTGCTTGGCAGGAGACCGCCTACCTGTTCC
GATCACCTGAGAACGCGCGACGCCTTCTTGATGCGTATGACCGGGCTCGTGCGGGCCACACGGAGATGCATGACCTCGAC
CAGGAGGACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT138897 WP_006638778.1 NZ_CP043501:1784624-1784905 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT138897 NZ_CP058259:510632-510886 [Actinomyces sp. oral taxon 169]
ATGCGTCTCGTATGGGACCCGTATGCTTGGGAGGACTATACGCACTGGCAGAAGGCGGACCGCCGGATCCTCAAACGGGT
CAACACGCTCATCGATGCGGCCCTTCGCGATCCCTTCGGAGGTATCGGTAAACCTGGGCGGCTCAAGTACGGCGCCTCGG
GTGCGTGGTCGCGAAGGATCACTGACGAGCATCGCCTCGTGTACCTCGTTGCTGGTGATGACCTGGTGATTCTCCAAGTT
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References