Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1944575..1946064 Replicon chromosome
Accession NZ_CP043498
Organism Rhizobium grahamii strain BG7

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag FZ934_RS09520 Protein ID WP_153270876.1
Coordinates 1944575..1945837 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag FZ934_RS09525 Protein ID WP_153270877.1
Coordinates 1945834..1946064 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZ934_RS27780 1941416..1943473 + 2058 WP_194273786.1 N-6 DNA methylase -
FZ934_RS09515 1943499..1944542 + 1044 WP_153270875.1 hypothetical protein -
FZ934_RS09520 1944575..1945837 - 1263 WP_153270876.1 type II toxin-antitoxin system HipA family toxin Toxin
FZ934_RS09525 1945834..1946064 - 231 WP_153270877.1 helix-turn-helix transcriptional regulator Antitoxin
FZ934_RS09530 1946537..1949761 + 3225 WP_153270878.1 hypothetical protein -
FZ934_RS09535 1949764..1950474 + 711 WP_018095597.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45632.20 Da        Isoelectric Point: 5.3395

>T138894 WP_153270876.1 NZ_CP043498:c1945837-1944575 [Rhizobium grahamii]
MTVRVLNVWWDGRIVGQFTQDRHGDIGFAYSEAWLRDENTLPLSASLPKRQERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQKPTEAGPIADQQPAPLDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKV
PLVLIDGQIALPVLGQATTHILKPPIARFPGTTENEAFVMRLAAAVGLDVAPVEPWSANGRPFLLIERYDRYRDADGVVR
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSERPGTDIAKLLDAAIFNLIVGNADAHGKNFSILYDDQGPRMA
PLYDLLSTVAYPDLSPKMAMRIGRRATLAEMDADGWKAFSKDTGVGLPLVRRRVAELTDATCGTIAQVRESLSPSAVDPV
TIKQVSTLIASRAQLVGSSL

Download         Length: 1263 bp

>T138894 NZ_CP043498:c1945837-1944575 [Rhizobium grahamii]
ATGACGGTAAGGGTTCTCAACGTCTGGTGGGATGGTCGTATTGTCGGGCAATTCACCCAGGATAGGCACGGTGATATTGG
CTTTGCCTACTCCGAAGCTTGGCTTCGTGACGAAAACACTCTTCCGCTGTCTGCCTCGCTCCCGAAGCGCCAAGAGCGTT
TTTCCCGTCGTGAATGCCGACCATTTTTCGGAGGCCTGTTGCCCGAGGAAAGCCAGCGTCTTGTTGCGGCGCAGGCATTG
GGCGTTTCACCTGCGAACGACTTCGCGCTTCTTGATCGCTTAGGCGGTGACGTTGCCGGCGCGCTTCAGCTTTTGCCGGA
AGATCAGAAACCCACAGAAGCGGGACCGATTGCGGATCAGCAACCAGCACCTCTGGATGAGGCCGGAATCGTTCGGATAC
TCGACGCACTTCCGACCCGGCCGCTATTGGCCGGCCAAGAGGGCTTGAGGCTATCGCTGGCTGGCGCGCAATCCAAGGTG
CCGCTTGTTCTAATCGACGGTCAGATCGCACTTCCGGTTCTCGGCCAGGCGACTACCCACATACTTAAGCCGCCGATCGC
ACGCTTCCCAGGGACAACCGAAAACGAAGCCTTCGTCATGAGGCTCGCTGCAGCGGTTGGCCTCGACGTTGCCCCCGTCG
AACCGTGGTCCGCGAATGGTCGCCCTTTTCTTTTGATCGAGCGATACGATCGCTACCGCGATGCCGACGGCGTGGTTCGC
CGCATACATCAGGAAGACTTTTGCCAAGCACTTGGTGTGCCGCCTGAAACGAAGTATGCAAGCGAGGGCGGACCGACATT
CAAGGACTGCTTCGAGCTATTGCGGCGGGTGTCTGAACGGCCGGGCACGGACATCGCGAAGTTACTGGACGCAGCAATCT
TCAATCTCATAGTTGGAAATGCTGACGCCCACGGCAAGAATTTTTCGATTCTGTATGACGACCAAGGGCCCCGAATGGCT
CCTTTGTACGACCTGCTTTCAACCGTGGCCTATCCAGACCTCTCACCGAAAATGGCTATGCGGATCGGGAGACGTGCGAC
CCTTGCCGAAATGGACGCCGACGGTTGGAAGGCTTTTTCGAAAGATACCGGTGTTGGCTTACCGTTGGTGCGCCGCCGAG
TTGCTGAGCTGACGGATGCCACCTGTGGAACGATAGCCCAAGTGCGCGAATCGCTATCTCCAAGCGCCGTTGACCCGGTT
ACGATCAAGCAGGTCTCGACCTTGATCGCGAGCCGCGCGCAGTTGGTAGGATCGTCACTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8155.62 Da        Isoelectric Point: 10.1140

>AT138894 WP_153270877.1 NZ_CP043498:c1946064-1945834 [Rhizobium grahamii]
MAKCIKTPADIGTLVRIARKEQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSVDILAPGERRK

Download         Length: 231 bp

>AT138894 NZ_CP043498:c1946064-1945834 [Rhizobium grahamii]
ATGGCGAAATGCATCAAAACTCCAGCCGATATCGGCACCCTGGTCCGCATCGCACGCAAGGAGCAAAACTTGCGGCAGGA
CGAACTTGCTGGCGTTTCTGGAGTCGGCCTCCGCTTCATTGTCGATCTCGAAGCCGGAAAGCCGACAGCTCAGATAGGAA
AAGTGTTGCAGGTTCTGCAAACGCTCGGCTGTTCCGTTGATATTCTGGCACCTGGTGAACGTAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References