Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 464823..465406 Replicon chromosome
Accession NZ_CP043498
Organism Rhizobium grahamii strain BG7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FZ934_RS02325 Protein ID WP_153269747.1
Coordinates 465035..465406 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FZ934_RS02320 Protein ID WP_153269746.1
Coordinates 464823..465041 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZ934_RS02295 460099..460518 + 420 WP_153269742.1 hypothetical protein -
FZ934_RS02300 460563..462050 - 1488 WP_153269743.1 sulfate adenylyltransferase subunit CysN -
FZ934_RS02305 462052..463005 - 954 WP_153269744.1 sulfate adenylyltransferase subunit CysD -
FZ934_RS02310 463118..463864 - 747 WP_153272338.1 phosphoadenylyl-sulfate reductase -
FZ934_RS02315 464281..464727 + 447 WP_153269745.1 Rrf2 family transcriptional regulator -
FZ934_RS02320 464823..465041 + 219 WP_153269746.1 ribbon-helix-helix domain-containing protein Antitoxin
FZ934_RS02325 465035..465406 + 372 WP_153269747.1 type II toxin-antitoxin system VapC family toxin Toxin
FZ934_RS02330 465403..466764 - 1362 WP_153269748.1 chloride channel protein -
FZ934_RS02335 466929..468577 - 1649 Protein_455 choline dehydrogenase -
FZ934_RS02340 468634..468879 + 246 WP_153269749.1 cytotoxic translational repressor of toxin-antitoxin stability system -
FZ934_RS02345 468883..469230 + 348 WP_153269750.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-105)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13568.53 Da        Isoelectric Point: 4.1621

>T138891 WP_153269747.1 NZ_CP043498:465035-465406 [Rhizobium grahamii]
MVKPLFDTNILIDYLNAVPQAAEEFDRYDTAAISIITWMEVLAGAAPDVADATRRFLAGFQIVSLEASVAERAVEIRQEY
RINLPDAIIWATADTNSMLLVTRNSKDFPADAPGVRIPYVLPA

Download         Length: 372 bp

>T138891 NZ_CP058253:1667705-1668226 [Enterobacter roggenkampii]
GTGGACAATCTCACGATCGAAATGTTTTCAGAGGGAAAAGACTATGATTTCAGGGACTTCGATTGTGGTGAACCCTCGCT
AAATGTCTTCCTCACAGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGGCTATTTGCTTAAAGATCGCGATG
GTCCGCGAGTCCTGGGCTATTACACGTTGTCTGGTAGTTGCTTTGAAAAAGCGATGCTGCCTTCTAAGACTCAGCAGCGT
CGGATCCCTTATAGCAACGTACCGAGCGTAACGCTGGGACGTCTGGCGATACATAAAGACTTACAGGGGCTGGAGTGGGG
AACGACGCTCGTCACGCATGCCATGCGGGTTGTCTATCTGGCATCGCAGGCGGTGGGCGTACACGGAATATTTGTTGATG
CACTCAACGACCAGGCAAAACAATTTTATCTGAAGCAGGGCTTTATTCCGCTGACGGATGAAAACAGCCATTCTCTTTTC
TTTCCTACAAAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7973.90 Da        Isoelectric Point: 5.0176

>AT138891 WP_153269746.1 NZ_CP043498:464823-465041 [Rhizobium grahamii]
VARTLVDIGDNDLKALDDLAATKNVSRASLIRKAVSAFLEQSSVDHRSQAFGLWGDRKVDGLAYQEEIRGEW

Download         Length: 219 bp

>AT138891 NZ_CP058253:1667429-1667698 [Enterobacter roggenkampii]
ATGCCAGCACTGAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGGGCAGCGGAAGTCATCGAGCAGCACCGCCGTC
TCGTATTAAACGAAGCATCCTGGAATGCGGTGATGGATGCCATCGACAATCCACCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References