Detailed information of TA system TA138887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4627973..4629308
• Replicon: chromosome
• Accession: NZ_CP043487
• Organism: Escherichia coli strain AQ15

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: E0J2C5
• Locus tag: FQT78_RS22340
• Protein ID: WP_000342500.1
• Coordinates: 4628361..4629308 (+)
• Length: 316 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: E0J2C6
• Locus tag: FQT78_RS22335
• Protein ID: WP_000152741.1
• Coordinates: 4627973..4628368 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQT78_RS22305	4623738..4624691	+	954	WP_000290405.1	hypothetical protein	-
FQT78_RS22310	4624927..4625745	+	819	WP_000761991.1	DUF945 domain-containing protein	-
FQT78_RS22315	4625775..4626248	+	474	WP_001292742.1	DNA repair protein RadC	-
FQT78_RS22320	4626248..4626583	+	336	WP_000939438.1	type IV toxin-antitoxin system YeeU family antitoxin	-
FQT78_RS22325	4626614..4626955	+	342	WP_000691790.1	TA system toxin CbtA family protein	-
FQT78_RS22330	4627070..4627903	+	834	WP_001192746.1	DUF4942 domain-containing protein	-
FQT78_RS22335	4627973..4628368	+	396	WP_000152741.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FQT78_RS22340	4628361..4629308	+	948	WP_000342500.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FQT78_RS22345	4629701..4630966	+	1266	WP_001218329.1	integrase arm-type DNA-binding domain-containing protein	-
FQT78_RS22350	4631167..4632636	-	1470	WP_001022619.1	serine/threonine protein kinase	-
FQT78_RS22355	4632633..4633046	-	414	WP_001368082.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	4610656..4659649	48993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-303)

Antitoxin

• Protein of unknown function DUF6088 (7-108)

Sequences

Toxin

Protein

• Length: 316 a.a.
• Molecular weight: 35562.71 Da
• Isoelectric Point: 4.9737

>T138887 WP_000342500.1 NZ_CP043487:4628361-4629308 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGSTGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Nucleotide

• Length: 948 bp

>T138887 NZ_CP058253:149525-149710 [Enterobacter roggenkampii]
GTGAAAAGTGCGGATGTCATTACTGTTCTGATCAGCCATGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCCAAGAAGGATATTAAACCGGGCACTCTCGCCCAGATCT
GGCGACAGGCGGGTATTAAAGACTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14619.93 Da
• Isoelectric Point: 11.6915

>AT138887 WP_000152741.1 NZ_CP043487:4627973-4628368 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Nucleotide

• Length: 396 bp

>AT138887 NZ_CP058253:149725-150132 [Enterobacter roggenkampii]
ATGTTTTATCCGGCTTACATTCATTCTGACTCCGACGGTAGCGCCAGCGGCTTTTTCCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCGCGTGATGCGCTCACAGCACACTTCGAAGCGCTATTTGAAATGG
ATAATGCACTGCCTCTTCCGGGTAATGTGGAAGCGCATCTGGAAAGTCGTCCTGAGGATTTCACTGGCGGGCAATGGCTG
TTGGTAGATATTAATATGAAACAGTTCGACGGTAGGGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
AATTGATTCCTTTGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CTGGGTAA

Structures

Toxin

• AlphaFold DB: E0J2C5

Antitoxin

• AlphaFold DB: A0A1L4ZXD4