Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yeeU/CbtA-CbeA |
| Location | 4626248..4626955 | Replicon | chromosome |
| Accession | NZ_CP043487 | ||
| Organism | Escherichia coli strain AQ15 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | E0J2C8 |
| Locus tag | FQT78_RS22325 | Protein ID | WP_000691790.1 |
| Coordinates | 4626614..4626955 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | FQT78_RS22320 | Protein ID | WP_000939438.1 |
| Coordinates | 4626248..4626583 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FQT78_RS22295 | 4622195..4622413 | - | 219 | WP_001064742.1 | AlpA family phage regulatory protein | - |
| FQT78_RS22300 | 4622531..4623145 | - | 615 | WP_000772909.1 | inovirus Gp2 family protein | - |
| FQT78_RS22305 | 4623738..4624691 | + | 954 | WP_000290405.1 | hypothetical protein | - |
| FQT78_RS22310 | 4624927..4625745 | + | 819 | WP_000761991.1 | DUF945 domain-containing protein | - |
| FQT78_RS22315 | 4625775..4626248 | + | 474 | WP_001292742.1 | DNA repair protein RadC | - |
| FQT78_RS22320 | 4626248..4626583 | + | 336 | WP_000939438.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FQT78_RS22325 | 4626614..4626955 | + | 342 | WP_000691790.1 | TA system toxin CbtA family protein | Toxin |
| FQT78_RS22330 | 4627070..4627903 | + | 834 | WP_001192746.1 | DUF4942 domain-containing protein | - |
| FQT78_RS22335 | 4627973..4628368 | + | 396 | WP_000152741.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| FQT78_RS22340 | 4628361..4629308 | + | 948 | WP_000342500.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| FQT78_RS22345 | 4629701..4630966 | + | 1266 | WP_001218329.1 | integrase arm-type DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB / fimE / fimA / fimI / fimC | 4610656..4659649 | 48993 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13060.08 Da Isoelectric Point: 9.4583
>T138886 WP_000691790.1 NZ_CP043487:4626614-4626955 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCYNTTAR
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCYNTTAR
Download Length: 342 bp
>T138886 NZ_CP058252:c1539085-1538321 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATTGCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAGGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAAAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAACAACAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGAGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGAAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTGCAATTCTATTTGTGATTGGTTTTGTG
GGAGAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTAA
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATTATTGTATTGCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAGGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAAAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAACAACAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGAGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGAAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTGCAATTCTATTTGTGATTGGTTTTGTG
GGAGAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12639.63 Da Isoelectric Point: 7.7723
>AT138886 WP_000939438.1 NZ_CP043487:4626248-4626583 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPWQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPWQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
Download Length: 336 bp
>AT138886 NZ_CP058252:c1539512-1539075 [Helicobacter pylori]
ATGGTTAATGCTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAGATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATACCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAGCACTC
TCGCAAAATCTTAGAAAAGATGAACTTGAAACCATCAACCACTCCATAGAAAAATGCAACAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAGACAAGAAGCCAAACAAGCAAATGGAAACTAA
ATGGTTAATGCTTTGGAACTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAGATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATACCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAGCACTC
TCGCAAAATCTTAGAAAAGATGAACTTGAAACCATCAACCACTCCATAGAAAAATGCAACAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAGACAAGAAGCCAAACAAGCAAATGGAAACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|