138885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4558958..4559553 Replicon chromosome
Accession NZ_CP043487
Organism Escherichia coli strain AQ15

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag FQT78_RS22005 Protein ID WP_000239579.1
Coordinates 4559203..4559553 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag FQT78_RS22000 Protein ID WP_001223208.1
Coordinates 4558958..4559209 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT78_RS21990 4554622..4558401 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
FQT78_RS21995 4558404..4558745 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
FQT78_RS22000 4558958..4559209 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
FQT78_RS22005 4559203..4559553 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
FQT78_RS22010 4559633..4560163 - 531 WP_000055072.1 inorganic diphosphatase -
FQT78_RS22015 4560473..4561429 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
FQT78_RS22020 4561569..4563071 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
FQT78_RS22025 4563085..4564107 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T138885 WP_000239579.1 NZ_CP043487:4559203-4559553 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T138885 NZ_CP058252:c77348-77067 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTAAAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTAAAAAAACAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTAAGTGGTAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT138885 WP_001223208.1 NZ_CP043487:4558958-4559209 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT138885 NZ_CP058252:c77655-77341 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAACGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References