Detailed information of TA system TA138883

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3941975..3942694
• Replicon: chromosome
• Accession: NZ_CP043487
• Organism: Escherichia coli strain AQ15

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: E0J373
• Locus tag: FQT78_RS19005
• Protein ID: WP_001095907.1
• Coordinates: 3942374..3942694 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: E0J374
• Locus tag: FQT78_RS19000
• Protein ID: WP_001192122.1
• Coordinates: 3941975..3942340 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQT78_RS18965	3937069..3937359	+	291	Protein_3713	hypothetical protein	-
FQT78_RS18975	3938784..3939587	+	804	WP_001245321.1	hypothetical protein	-
FQT78_RS18980	3939804..3940280	+	477	WP_001254693.1	hypothetical protein	-
FQT78_RS18985	3940352..3941173	+	822	WP_000197395.1	DUF945 domain-containing protein	-
FQT78_RS18990	3941243..3941713	+	471	WP_000104319.1	DNA repair protein RadC	-
FQT78_RS18995	3941722..3941943	+	222	WP_000691985.1	DUF987 family protein	-
FQT78_RS19000	3941975..3942340	+	366	WP_001192122.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FQT78_RS19005	3942374..3942694	+	321	WP_001095907.1	TA system toxin CbtA family protein	Toxin
FQT78_RS19015	3943461..3944645	+	1185	WP_001172876.1	sugar efflux transporter	-
FQT78_RS19020	3944756..3945679	+	924	WP_000535960.1	carboxylate/amino acid/amine transporter	-
FQT78_RS19025	3945683..3945946	-	264	Protein_3724	lipoprotein NlpA	-
FQT78_RS19030	3945961..3947169	-	1209	WP_001339197.1	IS4-like element ISVsa5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3926047..3947169	21122
	-	flank	IS/Tn	-	-	3945961..3947169	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-104)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12184.76 Da
• Isoelectric Point: 5.5740

>T138883 WP_001095907.1 NZ_CP043487:3942374-3942694 [Escherichia coli]
MNTPTVPATVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVRRAQFNLGLKRS

Nucleotide

• Length: 321 bp

>T138883 NZ_CP058243:c4537580-4537428 [Xanthomonas campestris pv. raphani]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13470.22 Da
• Isoelectric Point: 6.8421

>AT138883 WP_001192122.1 NZ_CP043487:3941975-3942340 [Escherichia coli]
MQSTTLSGTSAENVSCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTAGE
LDPRSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPQSALTR

Nucleotide

• Length: 366 bp

>AT138883 NZ_CP043487:3941975-3942340 [Escherichia coli]
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGTATCCTGCCTTCAGTGGGGTTTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCCTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGATGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCGGATGCTGACGGCTGGCGAG
CTTGATCCTCGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATTGCCATATATCCCCAGTCAGCTCTAACCAGATAA

Structures

Toxin

• AlphaFold DB: E0J373

Antitoxin

• AlphaFold DB: E0J374