138878

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2670443..2671068 Replicon chromosome
Accession NZ_CP043487
Organism Escherichia coli strain AQ15

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag FQT78_RS12895 Protein ID WP_000911329.1
Coordinates 2670443..2670841 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag FQT78_RS12900 Protein ID WP_000450524.1
Coordinates 2670841..2671068 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT78_RS12875 2666350..2666550 + 201 WP_000383836.1 YpfN family protein -
FQT78_RS12880 2666631..2667329 - 699 WP_000679823.1 esterase -
FQT78_RS12885 2667403..2669418 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
FQT78_RS12890 2669433..2670296 - 864 WP_001267505.1 neutral zinc metallopeptidase -
FQT78_RS12895 2670443..2670841 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
FQT78_RS12900 2670841..2671068 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
FQT78_RS12905 2671223..2671936 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FQT78_RS12910 2672149..2673183 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
FQT78_RS12915 2673200..2674078 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
FQT78_RS12920 2674224..2674796 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
FQT78_RS12925 2674796..2675266 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T138878 WP_000911329.1 NZ_CP043487:c2670841-2670443 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T138878 NZ_CP058242:c2219964-2219788 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT138878 WP_000450524.1 NZ_CP043487:c2671068-2670841 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT138878 NZ_CP058242:2219747-2219847 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References