Detailed information of TA system TA138858

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4664890..4666225
• Replicon: chromosome
• Accession: NZ_CP043486
• Organism: Escherichia coli strain SL112

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: E0J2C5
• Locus tag: FQT94_RS22460
• Protein ID: WP_000342500.1
• Coordinates: 4665278..4666225 (+)
• Length: 316 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: E0J2C6
• Locus tag: FQT94_RS22455
• Protein ID: WP_000152741.1
• Coordinates: 4664890..4665285 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQT94_RS22425	4660655..4661608	+	954	WP_000290405.1	hypothetical protein	-
FQT94_RS22430	4661844..4662662	+	819	WP_000761991.1	DUF945 domain-containing protein	-
FQT94_RS22435	4662692..4663165	+	474	WP_001292742.1	DNA repair protein RadC	-
FQT94_RS22440	4663165..4663500	+	336	WP_000939438.1	type IV toxin-antitoxin system YeeU family antitoxin	-
FQT94_RS22445	4663531..4663872	+	342	WP_000691790.1	TA system toxin CbtA family protein	-
FQT94_RS22450	4663987..4664820	+	834	WP_001192746.1	DUF4942 domain-containing protein	-
FQT94_RS22455	4664890..4665285	+	396	WP_000152741.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FQT94_RS22460	4665278..4666225	+	948	WP_000342500.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FQT94_RS22465	4666618..4667883	+	1266	WP_001218329.1	integrase arm-type DNA-binding domain-containing protein	-
FQT94_RS22470	4668084..4669553	-	1470	WP_001022619.1	serine/threonine protein kinase	-
FQT94_RS22475	4669550..4669963	-	414	WP_001368082.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	4647573..4696566	48993

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-303)

Antitoxin

• Protein of unknown function DUF6088 (7-108)

Sequences

Toxin

Protein

• Length: 316 a.a.
• Molecular weight: 35562.71 Da
• Isoelectric Point: 4.9737

>T138858 WP_000342500.1 NZ_CP043486:4665278-4666225 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGSTGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Nucleotide

• Length: 948 bp

>T138858 NZ_CP058236:2891549-2891926 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14619.93 Da
• Isoelectric Point: 11.6915

>AT138858 WP_000152741.1 NZ_CP043486:4664890-4665285 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Nucleotide

• Length: 396 bp

>AT138858 NZ_CP058236:2891295-2891552 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGACTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Structures

Toxin

• AlphaFold DB: E0J2C5

Antitoxin

• AlphaFold DB: A0A1L4ZXD4