Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3128770..3129424 Replicon chromosome
Accession NZ_CP043486
Organism Escherichia coli strain SL112

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag FQT94_RS15055 Protein ID WP_000244772.1
Coordinates 3128770..3129177 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FQT94_RS15060 Protein ID WP_000354046.1
Coordinates 3129158..3129424 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT94_RS15035 3124727..3126460 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
FQT94_RS15040 3126466..3127176 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FQT94_RS15045 3127201..3128097 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FQT94_RS15050 3128209..3128730 + 522 WP_001055874.1 flavodoxin FldB -
FQT94_RS15055 3128770..3129177 - 408 WP_000244772.1 protein YgfX Toxin
FQT94_RS15060 3129158..3129424 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FQT94_RS15065 3129667..3130647 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
FQT94_RS15070 3130724..3131383 - 660 WP_000250274.1 hemolysin III family protein -
FQT94_RS15075 3131547..3131858 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
FQT94_RS15080 3131903..3133336 + 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
FQT94_RS15085 3133393..3134136 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T138850 WP_000244772.1 NZ_CP043486:c3129177-3128770 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T138850 NZ_CP058236:c2258174-2257830 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT138850 WP_000354046.1 NZ_CP043486:c3129424-3129158 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT138850 NZ_CP043486:c3129424-3129158 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References