138848

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2659499..2660124 Replicon chromosome
Accession NZ_CP043486
Organism Escherichia coli strain SL112

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag FQT94_RS12850 Protein ID WP_000911329.1
Coordinates 2659499..2659897 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag FQT94_RS12855 Protein ID WP_000450524.1
Coordinates 2659897..2660124 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT94_RS12830 2655406..2655606 + 201 WP_000383836.1 YpfN family protein -
FQT94_RS12835 2655687..2656385 - 699 WP_000679823.1 esterase -
FQT94_RS12840 2656459..2658474 - 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
FQT94_RS12845 2658489..2659352 - 864 WP_001267505.1 neutral zinc metallopeptidase -
FQT94_RS12850 2659499..2659897 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
FQT94_RS12855 2659897..2660124 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
FQT94_RS12860 2660279..2660992 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
FQT94_RS12865 2661205..2662239 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
FQT94_RS12870 2662256..2663134 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
FQT94_RS12875 2663280..2663852 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
FQT94_RS12880 2663852..2664322 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T138848 WP_000911329.1 NZ_CP043486:c2659897-2659499 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T138848 NZ_CP043486:c2659897-2659499 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT138848 WP_000450524.1 NZ_CP043486:c2660124-2659897 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT138848 NZ_CP058236:c2249625-2249365 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References