138838

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1714834..1715360 Replicon chromosome
Accession NZ_CP043486
Organism Escherichia coli strain SL112

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FQT94_RS08225 Protein ID WP_000323025.1
Coordinates 1714834..1715121 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag FQT94_RS08230 Protein ID WP_000534858.1
Coordinates 1715121..1715360 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT94_RS08180 1709858..1710073 - 216 WP_000839590.1 phage lysis protein EssD -
FQT94_RS08185 1710827..1711042 - 216 WP_000066484.1 cold shock-like protein CspB -
FQT94_RS08190 1711343..1711555 + 213 WP_000087756.1 cold shock-like protein CspF -
FQT94_RS08195 1711610..1711699 + 90 WP_120795389.1 hypothetical protein -
FQT94_RS08200 1711977..1712729 - 753 WP_001047135.1 antitermination protein -
FQT94_RS08205 1712743..1713792 - 1050 WP_001265199.1 DUF968 domain-containing protein -
FQT94_RS08210 1713794..1714072 - 279 WP_012304870.1 hypothetical protein -
FQT94_RS08215 1714139..1714390 - 252 WP_000980994.1 hypothetical protein -
FQT94_RS08220 1714607..1714762 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
FQT94_RS08225 1714834..1715121 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FQT94_RS08230 1715121..1715360 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FQT94_RS08235 1715385..1715690 + 306 WP_001326990.1 hypothetical protein -
FQT94_RS08240 1715893..1716225 + 333 WP_001301033.1 protein FlxA -
FQT94_RS08245 1716662..1717975 - 1314 WP_000589005.1 ISNCY family transposase -
FQT94_RS23105 1718744..1719031 - 288 Protein_1619 hypothetical protein -
FQT94_RS08255 1719642..1719998 - 357 WP_001310834.1 class I SAM-dependent methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1678096..1729861 51765


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T138838 WP_000323025.1 NZ_CP043486:c1715121-1714834 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T138838 NZ_CP058236:c1394696-1394403 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT138838 WP_000534858.1 NZ_CP043486:c1715360-1715121 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT138838 NZ_CP058236:c1394962-1394693 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References