138830

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 517534..518371 Replicon chromosome
Accession NZ_CP043486
Organism Escherichia coli strain SL112

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag FQT94_RS02475 Protein ID WP_000227784.1
Coordinates 517534..518076 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag FQT94_RS02480 Protein ID WP_001297137.1
Coordinates 518060..518371 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT94_RS02455 513084..513995 - 912 WP_000705849.1 2-dehydropantoate 2-reductase -
FQT94_RS02460 514163..514654 + 492 WP_001138904.1 nucleotide binding protein YajQ -
FQT94_RS02465 514782..516146 - 1365 WP_001000978.1 MFS transporter -
FQT94_RS02470 516554..517478 + 925 Protein_487 sel1 repeat family protein -
FQT94_RS02475 517534..518076 - 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
FQT94_RS02480 518060..518371 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
FQT94_RS02485 518556..519446 - 891 WP_000971336.1 heme o synthase -
FQT94_RS02490 519458..519787 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
FQT94_RS02495 519787..520401 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
FQT94_RS02500 520391..522382 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
FQT94_RS02505 522404..523351 - 948 WP_001239440.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T138830 WP_000227784.1 NZ_CP043486:c518076-517534 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T138830 NZ_CP058236:c760471-760034 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT138830 WP_001297137.1 NZ_CP043486:c518371-518060 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT138830 NZ_CP058236:c759924-759679 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References