Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1110012..1110505 Replicon chromosome
Accession NZ_CP043484
Organism Enterococcus faecium strain DMEA02

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag FZP47_RS05505 Protein ID WP_002329323.1
Coordinates 1110239..1110505 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag FZP47_RS05500 Protein ID WP_002329324.1
Coordinates 1110012..1110242 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZP47_RS05460 1105017..1105784 + 768 WP_002329331.1 MurR/RpiR family transcriptional regulator -
FZP47_RS05465 1105785..1106228 + 444 WP_002329330.1 hypothetical protein -
FZP47_RS05470 1106438..1107027 - 590 Protein_1053 glutamine amidotransferase -
FZP47_RS05475 1107674..1108633 - 960 WP_002293280.1 IS30-like element IS6770 family transposase -
FZP47_RS05480 1108883..1109188 + 306 WP_002329327.1 hypothetical protein -
FZP47_RS05485 1109201..1109536 + 336 WP_002329326.1 hypothetical protein -
FZP47_RS05500 1110012..1110242 + 231 WP_002329324.1 hypothetical protein Antitoxin
FZP47_RS05505 1110239..1110505 + 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FZP47_RS05510 1110757..1110984 + 228 WP_002329322.1 hypothetical protein -
FZP47_RS05515 1111000..1112166 + 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
FZP47_RS05520 1112399..1113442 + 1044 WP_002329320.1 heat-inducible transcriptional repressor HrcA -
FZP47_RS05525 1113536..1114099 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1107674..1108633 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T138826 WP_002329323.1 NZ_CP043484:1110239-1110505 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T138826 NZ_CP058236:720830-721225 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT138826 WP_002329324.1 NZ_CP043484:1110012-1110242 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT138826 NZ_CP058236:720576-720830 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References