Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4162386..4163220 Replicon chromosome
Accession NZ_CP043478
Organism Escherichia coli strain ST130

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag FZ043_RS20770 Protein ID WP_021527014.1
Coordinates 4162843..4163220 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FZ043_RS20765 Protein ID WP_032261140.1
Coordinates 4162386..4162754 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZ043_RS20745 4160142..4160960 + 819 WP_032261137.1 DUF945 domain-containing protein -
FZ043_RS20750 4161051..4161536 + 486 WP_021526886.1 antirestriction protein -
FZ043_RS20755 4161552..4162028 + 477 WP_032261139.1 RadC family protein -
FZ043_RS20760 4162091..4162312 + 222 WP_000692320.1 DUF987 domain-containing protein -
FZ043_RS20765 4162386..4162754 + 369 WP_032261140.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FZ043_RS20770 4162843..4163220 + 378 WP_021527014.1 type IV toxin-antitoxin system toxin CbtA Toxin
FZ043_RS20775 4163217..4163366 + 150 Protein_3959 hypothetical protein -
FZ043_RS20780 4163442..4163639 + 198 WP_089078746.1 DUF957 domain-containing protein -
FZ043_RS20785 4163724..4164284 + 561 Protein_3961 DUF4942 domain-containing protein -
FZ043_RS20790 4164651..4165187 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
FZ043_RS20795 4165189..4166367 - 1179 WP_000094989.1 type II secretion system protein GspL -
FZ043_RS20800 4166364..4167341 - 978 WP_000633239.1 type II secretion system minor pseudopilin GspK -
FZ043_RS20805 4167338..4167943 - 606 WP_001255030.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14010.13 Da        Isoelectric Point: 9.1378

>T138823 WP_021527014.1 NZ_CP043478:4162843-4163220 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLGQHYGLTLDDTPFADERVIEQHIKAGISLCDAVNFLVEKYTLVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEVKR

Download         Length: 378 bp

>T138823 NZ_CP058236:c701727-701314 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGATACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.60 Da        Isoelectric Point: 6.6209

>AT138823 WP_032261140.1 NZ_CP043478:4162386-4162754 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT138823 NZ_CP058236:c701960-701724 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References