Detailed information of TA system TA138804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 40133..40920
• Replicon: plasmid unnamed
• Accession: NZ_CP043477
• Organism: Xanthomonas hyacinthi strain CFBP 1156

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: -
• Locus tag: FZ025_RS21775
• Protein ID: WP_104558928.1
• Coordinates: 40318..40920 (+)
• Length: 201 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: A0A8B6LZM3
• Locus tag: FZ025_RS21770
• Protein ID: WP_011171677.1
• Coordinates: 40133..40321 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZ025_RS21730	35141..35398	+	258	WP_011171686.1	transcriptional repressor protein KorC	-
FZ025_RS21735	35589..35846	+	258	WP_104558931.1	stable inheritance protein KleA	-
FZ025_RS21740	35963..36286	+	324	WP_075122821.1	protein kleE	-
FZ025_RS21745	36288..36545	+	258	WP_031944036.1	hypothetical protein	-
FZ025_RS21750	36708..37016	+	309	WP_031944035.1	transcriptional regulator KorA	-
FZ025_RS21755	37013..37786	+	774	WP_104558930.1	ParA family protein	-
FZ025_RS21760	37783..38856	+	1074	WP_031944033.1	ParB/RepB/Spo0J family partition protein	-
FZ025_RS21765	39052..40068	+	1017	WP_104558929.1	DNA-binding protein	-
FZ025_RS21770	40133..40321	+	189	WP_011171677.1	antitoxin VbhA family protein	Antitoxin
FZ025_RS21775	40318..40920	+	603	WP_104558928.1	Fic/DOC family protein	Toxin
FZ025_RS21780	40944..41288	+	345	WP_104558927.1	conjugal transfer protein TraO	-
FZ025_RS21785	41340..41969	+	630	WP_104558938.1	hypothetical protein	-
FZ025_RS21790	42039..42476	-	438	WP_011171734.1	conjugal transfer protein TraM	-
FZ025_RS21795	42476..43201	-	726	WP_011171733.1	conjugal transfer protein TraL	-
FZ025_RS21800	43201..43602	-	402	WP_158185625.1	TraK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..44381	44381

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-150)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 201 a.a.
• Molecular weight: 22187.00 Da
• Isoelectric Point: 7.4661

>T138804 WP_104558928.1 NZ_CP043477:40318-40920 [Xanthomonas hyacinthi]
MKYAGDRGDPYLDSETGVLRNLLGIKEQGGLDKAESTLSFLRASELREQPVKGKFDLAHLQRIHKRLFGDVYDWAGQIRQ
VEISKGSTMFARQVAIQSAAQQLFGQLAKEQLLRGLDADEFSKRAGHYLGEINVLHPFREGNGRTQREFIGQLAQQAGHR
IDWSGVSQASMTQASIEAYNGDSSGMAGLIRAGMPDQIFF

Nucleotide

• Length: 603 bp

>T138804 NZ_CP043477:40318-40920 [Xanthomonas hyacinthi]
ATGAAATACGCCGGGGATCGCGGCGATCCTTACCTGGACAGCGAAACGGGTGTTCTCCGCAATCTCCTTGGAATCAAGGA
ACAGGGTGGACTCGATAAAGCCGAATCCACCCTTTCCTTTTTGCGGGCCAGCGAATTGCGCGAGCAGCCCGTTAAAGGCA
AATTCGATTTAGCGCACCTGCAGCGAATTCACAAGCGCCTTTTTGGCGACGTGTACGACTGGGCGGGCCAAATCCGCCAG
GTCGAAATCTCGAAAGGCAGCACCATGTTTGCCCGGCAGGTTGCGATCCAGAGCGCGGCGCAGCAGCTCTTTGGGCAGCT
TGCCAAGGAACAACTCTTGCGCGGCCTCGATGCCGACGAGTTCAGCAAGCGGGCCGGCCACTATCTCGGGGAAATCAACG
TGCTTCATCCCTTCCGTGAAGGGAACGGCAGGACGCAGCGTGAGTTCATCGGGCAACTGGCCCAGCAGGCGGGCCACAGG
ATCGACTGGAGCGGGGTCAGTCAGGCCAGCATGACCCAGGCGTCAATCGAAGCCTACAACGGCGACTCAAGCGGTATGGC
TGGCCTTATTCGCGCTGGCATGCCAGACCAGATTTTTTTTTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6904.79 Da
• Isoelectric Point: 4.4982

>AT138804 WP_011171677.1 NZ_CP043477:40133-40321 [Xanthomonas hyacinthi]
MIAEQEQTERRAVVQSALASQRIEGLEPDAQAVADAERWARGEMTIGAAVDQYKARMRLEMA

Nucleotide

• Length: 189 bp

>AT138804 NZ_CP043477:40133-40321 [Xanthomonas hyacinthi]
ATGATCGCAGAGCAGGAACAGACCGAGCGCCGCGCCGTGGTGCAAAGCGCCCTTGCGAGCCAGCGCATCGAGGGCTTAGA
GCCTGATGCGCAGGCCGTGGCCGACGCCGAGCGCTGGGCGCGTGGCGAGATGACCATCGGTGCCGCCGTGGACCAGTACA
AGGCGCGCATGCGGCTAGAAATGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B6LZM3