Detailed information of TA system TA138803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3441999..3442645
• Replicon: chromosome
• Accession: NZ_CP043476
• Organism: Xanthomonas hyacinthi strain CFBP 1156

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FZ025_RS15215
• Protein ID: WP_046980690.1
• Coordinates: 3442232..3442645 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FZ025_RS15210
• Protein ID: WP_046980689.1
• Coordinates: 3441999..3442235 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZ025_RS15195	3437426..3438676	+	1251	WP_104559004.1	efflux RND transporter periplasmic adaptor subunit	-
FZ025_RS15200	3438695..3439465	+	771	WP_104559000.1	ABC transporter ATP-binding protein	-
FZ025_RS15205	3439462..3441903	+	2442	WP_104559001.1	ABC transporter permease	-
FZ025_RS15210	3441999..3442235	+	237	WP_046980689.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FZ025_RS15215	3442232..3442645	+	414	WP_046980690.1	type II toxin-antitoxin system VapC family toxin	Toxin
FZ025_RS15220	3442656..3443870	+	1215	WP_046980691.1	sigma-54 dependent transcriptional regulator	-
FZ025_RS22035	3444674..3445177	+	504	WP_208803819.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-127)

Antitoxin

• SpoVT-AbrB domain (8-43)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14961.29 Da
• Isoelectric Point: 8.9416

>T138803 WP_046980690.1 NZ_CP043476:3442232-3442645 [Xanthomonas hyacinthi]
MSQPLYLLDTNICIYIINRRPPGVLDRFAALRIGQVAISSITGAELAYGVDKSGSPRNRQALDKFLAPLDILPFDEAAMR
RYGALRSGLERKGTSIGALDQLIAAHALALDAVLVTNNVREFERVAGLRLENWVSPA

Nucleotide

• Length: 414 bp

>T138803 NZ_CP058226:c4719824-4719291 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8933.25 Da
• Isoelectric Point: 6.3109

>AT138803 WP_046980689.1 NZ_CP043476:3441999-3442235 [Xanthomonas hyacinthi]
MTTTAKLFQSGRSQAVRLPKALRFEGEAVIARRFGNGVLLLPLDAPWQLLREALEEFEPGFQLQREQPEQQVRGEWPV

Nucleotide

• Length: 237 bp

>AT138803 NZ_CP058226:c4720101-4719835 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA