Detailed information of TA system TA138798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1002524..1003116
• Replicon: chromosome
• Accession: NZ_CP043476
• Organism: Xanthomonas hyacinthi strain CFBP 1156

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: FZ025_RS04600
• Protein ID: WP_046978042.1
• Coordinates: 1002524..1002820 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: FZ025_RS04605
• Protein ID: WP_046978041.1
• Coordinates: 1002823..1003116 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZ025_RS04585	997867..999030	-	1164	WP_046978047.1	ADP-forming succinate--CoA ligase subunit beta	-
FZ025_RS04590	999274..1000887	+	1614	WP_104557685.1	HAMP domain-containing histidine kinase	-
FZ025_RS04595	1000963..1002351	+	1389	WP_104557687.1	sigma-54 dependent transcriptional regulator	-
FZ025_RS04600	1002524..1002820	+	297	WP_046978042.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FZ025_RS04605	1002823..1003116	+	294	WP_046978041.1	putative addiction module antidote protein	Antitoxin
FZ025_RS04610	1003144..1004880	-	1737	WP_046978045.1	type IV-A pilus assembly ATPase PilB	-
FZ025_RS04615	1005088..1005378	+	291	WP_046978040.1	nucleotidyltransferase family protein	-
FZ025_RS04620	1005375..1005746	+	372	WP_046978039.1	DUF86 domain-containing protein	-
FZ025_RS04625	1005882..1006577	+	696	WP_104557689.1	transposase	-
FZ025_RS04630	1006977..1007414	-	438	WP_046978037.1	pilin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (39-91)

Antitoxin

• Uncharacterized protein HI1420 (4-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11204.82 Da
• Isoelectric Point: 10.3974

>T138798 WP_046978042.1 NZ_CP043476:1002524-1002820 [Xanthomonas hyacinthi]
VIELKQTETFRKWRTKLKDERARTAIALRLTRLAYGHAGDTEPVGQGISELRIHYGPGYRVYFQRRGNTIVVLLCGGDKS
TQAKDIKTAKRLADEWSE

Nucleotide

• Length: 297 bp

>T138798 NZ_CP058226:741586-742071 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10386.73 Da
• Isoelectric Point: 4.9890

>AT138798 WP_046978041.1 NZ_CP043476:1002823-1003116 [Xanthomonas hyacinthi]
MTENLTTYDPAEDLNSDQAIADFMAGAFATNDPGFIAHALGIVARAKGMTQIARQTGLSREQLYRSFSEDGNPTLRTTLA
VMKALGIELTAKAAITH

Nucleotide

• Length: 294 bp

>AT138798 NZ_CP058226:741296-741589 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA