Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4334609..4335620 Replicon chromosome
Accession NZ_CP043474
Organism Mycobacterium grossiae strain DSM 104744

Toxin (Protein)


Gene name pezT Uniprot ID A0A1E8Q358
Locus tag FZ046_RS20875 Protein ID WP_070353759.1
Coordinates 4334609..4335181 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1E8Q3S8
Locus tag FZ046_RS20880 Protein ID WP_070353758.1
Coordinates 4335216..4335620 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZ046_RS20840 4330259..4330393 + 135 WP_083298298.1 DUF2256 domain-containing protein -
FZ046_RS20845 4330397..4330768 - 372 WP_070353764.1 hypothetical protein -
FZ046_RS20850 4330835..4331446 + 612 WP_070353763.1 NAD(P)H-dependent oxidoreductase -
FZ046_RS20855 4331456..4332094 - 639 WP_070353809.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
FZ046_RS20860 4332179..4333336 + 1158 WP_099045948.1 AI-2E family transporter -
FZ046_RS20865 4333359..4333634 - 276 WP_070353761.1 hypothetical protein -
FZ046_RS20870 4333766..4334446 - 681 WP_070353760.1 sensor domain-containing protein -
FZ046_RS20875 4334609..4335181 - 573 WP_070353759.1 zeta toxin family protein Toxin
FZ046_RS20880 4335216..4335620 - 405 WP_070353758.1 hypothetical protein Antitoxin
FZ046_RS20885 4335704..4336291 - 588 WP_070353757.1 TetR/AcrR family transcriptional regulator -
FZ046_RS20890 4336393..4336869 + 477 WP_070353756.1 DUF1772 domain-containing protein -
FZ046_RS20895 4336914..4337219 + 306 WP_070353755.1 NIPSNAP family protein -
FZ046_RS20900 4337232..4337594 + 363 WP_070353754.1 DUF4267 domain-containing protein -
FZ046_RS20905 4337612..4338076 - 465 WP_070353753.1 MarR family transcriptional regulator -
FZ046_RS20910 4338139..4338594 + 456 WP_070353752.1 hypothetical protein -
FZ046_RS20915 4338612..4339469 + 858 WP_083298290.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 20742.92 Da        Isoelectric Point: 10.4952

>T138796 WP_070353759.1 NZ_CP043474:c4335181-4334609 [Mycobacterium grossiae]
VKRLDLVVGPNGAGKSTFVELTLAPLLPRHVFVNADEIAKLRWPDDPAAHAYEAARIAADTRARLIDLGRSFIAETVFSH
PSKLELIDAARRAGYTVALHVLMVPEDLSVERVARRVRHGGHSVPEAKIRERHRRLWDLVRTAVGMADVATVYDGSHREG
PRIVAQLTAGVVIGAPRWPAWTPAPLAGLG

Download         Length: 573 bp

>T138796 NZ_CP058226:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 13942.25 Da        Isoelectric Point: 4.5070

>AT138796 WP_070353758.1 NZ_CP043474:c4335620-4335216 [Mycobacterium grossiae]
MTNVADRVTRVASDLVESAAAEGARQSRSAKQQLDHWARVGRAVSSHQSASRRRIEAALAGDLDVTALTDDEGTVFGAEV
SAAIEESLATADYGAVLAARGITTVALDANGDIVEYRPDGSTSVVDIAGSRRAE

Download         Length: 405 bp

>AT138796 NZ_CP058226:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E8Q358

Antitoxin

Source ID Structure
AlphaFold DB A0A1E8Q3S8

References