Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4334609..4335620 Replicon chromosome
Accession NZ_CP043474
Organism Mycobacterium grossiae strain DSM 104744

Toxin (Protein)


Gene name pezT Uniprot ID A0A1E8Q358
Locus tag FZ046_RS20875 Protein ID WP_070353759.1
Coordinates 4334609..4335181 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1E8Q3S8
Locus tag FZ046_RS20880 Protein ID WP_070353758.1
Coordinates 4335216..4335620 (-) Length 135 a.a.

Genomic Context

FZ046_RS20840FZ046_RS20850FZ046_RS20860FZ046_RS20890FZ046_RS20895FZ046_RS20900FZ046_RS20910FZ046_RS20915FZ046_RS20845FZ046_RS20855FZ046_RS20865FZ046_RS20870FZ046_RS20875FZ046_RS20880FZ046_RS20885FZ046_RS20905
Location: 4330259..4330393 (135 bp)
Type: Others
Protein ID: WP_083298298.1
Location: 4330835..4331446 (612 bp)
Type: Others
Protein ID: WP_070353763.1
Location: 4332179..4333336 (1158 bp)
Type: Others
Protein ID: WP_099045948.1
Location: 4336393..4336869 (477 bp)
Type: Others
Protein ID: WP_070353756.1
Location: 4336914..4337219 (306 bp)
Type: Others
Protein ID: WP_070353755.1
Location: 4337232..4337594 (363 bp)
Type: Others
Protein ID: WP_070353754.1
Location: 4338139..4338594 (456 bp)
Type: Others
Protein ID: WP_070353752.1
Location: 4338612..4339469 (858 bp)
Type: Others
Protein ID: WP_083298290.1
Location: 4330397..4330768 (372 bp)
Type: Others
Protein ID: WP_070353764.1
Location: 4331456..4332094 (639 bp)
Type: Others
Protein ID: WP_070353809.1
Location: 4333359..4333634 (276 bp)
Type: Others
Protein ID: WP_070353761.1
Location: 4333766..4334446 (681 bp)
Type: Others
Protein ID: WP_070353760.1
Location: 4334609..4335181 (573 bp)
Type: Toxin
Protein ID: WP_070353759.1
Location: 4335216..4335620 (405 bp)
Type: Antitoxin
Protein ID: WP_070353758.1
Location: 4335704..4336291 (588 bp)
Type: Others
Protein ID: WP_070353757.1
Location: 4337612..4338076 (465 bp)
Type: Others
Protein ID: WP_070353753.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FZ046_RS208404330259..4330393+135WP_083298298.1DUF2256 domain-containing protein-
FZ046_RS208454330397..4330768-372WP_070353764.1hypothetical protein-
FZ046_RS208504330835..4331446+612WP_070353763.1NAD(P)H-dependent oxidoreductase-
FZ046_RS208554331456..4332094-639WP_070353809.1FKBP-type peptidyl-prolyl cis-trans isomerase-
FZ046_RS208604332179..4333336+1158WP_099045948.1AI-2E family transporter-
FZ046_RS208654333359..4333634-276WP_070353761.1hypothetical protein-
FZ046_RS208704333766..4334446-681WP_070353760.1sensor domain-containing protein-
FZ046_RS208754334609..4335181-573WP_070353759.1zeta toxin family proteinToxin
FZ046_RS208804335216..4335620-405WP_070353758.1hypothetical proteinAntitoxin
FZ046_RS208854335704..4336291-588WP_070353757.1TetR/AcrR family transcriptional regulator-
FZ046_RS208904336393..4336869+477WP_070353756.1DUF1772 domain-containing protein-
FZ046_RS208954336914..4337219+306WP_070353755.1NIPSNAP family protein-
FZ046_RS209004337232..4337594+363WP_070353754.1DUF4267 domain-containing protein-
FZ046_RS209054337612..4338076-465WP_070353753.1MarR family transcriptional regulator-
FZ046_RS209104338139..4338594+456WP_070353752.1hypothetical protein-
FZ046_RS209154338612..4339469+858WP_083298290.1NAD(P)-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 20742.92 Da        Isoelectric Point: 10.4952

>T138796 WP_070353759.1 NZ_CP043474:c4335181-4334609 [Mycobacterium grossiae]
VKRLDLVVGPNGAGKSTFVELTLAPLLPRHVFVNADEIAKLRWPDDPAAHAYEAARIAADTRARLIDLGRSFIAETVFSH
PSKLELIDAARRAGYTVALHVLMVPEDLSVERVARRVRHGGHSVPEAKIRERHRRLWDLVRTAVGMADVATVYDGSHREG
PRIVAQLTAGVVIGAPRWPAWTPAPLAGLG

Download         Length: 573 bp

>T138796 NZ_CP058226:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 13942.25 Da        Isoelectric Point: 4.5070

>AT138796 WP_070353758.1 NZ_CP043474:c4335620-4335216 [Mycobacterium grossiae]
MTNVADRVTRVASDLVESAAAEGARQSRSAKQQLDHWARVGRAVSSHQSASRRRIEAALAGDLDVTALTDDEGTVFGAEV
SAAIEESLATADYGAVLAARGITTVALDANGDIVEYRPDGSTSVVDIAGSRRAE

Download         Length: 405 bp

>AT138796 NZ_CP058226:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E8Q358

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E8Q3S8

References