Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-Xre
Location 2959022..2959920 Replicon chromosome
Accession NZ_CP043474
Organism Mycobacterium grossiae strain DSM 104744

Toxin (Protein)


Gene name mbcT Uniprot ID A0A1E8Q7U4
Locus tag FZ046_RS14185 Protein ID WP_070352248.1
Coordinates 2959360..2959920 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID A0A1E8Q7J7
Locus tag FZ046_RS14180 Protein ID WP_070352249.1
Coordinates 2959022..2959363 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZ046_RS14160 2956091..2956798 - 708 WP_176749520.1 hypothetical protein -
FZ046_RS14170 2957783..2958643 - 861 WP_083298103.1 hypothetical protein -
FZ046_RS14175 2958712..2958934 - 223 Protein_2807 hypothetical protein -
FZ046_RS14180 2959022..2959363 + 342 WP_070352249.1 DUF2384 domain-containing protein Antitoxin
FZ046_RS14185 2959360..2959920 + 561 WP_070352248.1 RES domain-containing protein Toxin
FZ046_RS14190 2959910..2960722 + 813 WP_070352247.1 AraC family transcriptional regulator -
FZ046_RS14195 2960776..2961738 + 963 WP_070352246.1 sterol desaturase family protein -
FZ046_RS14200 2961756..2962157 + 402 WP_176749521.1 metalloregulator ArsR/SmtB family transcription factor -
FZ046_RS14205 2962154..2964058 + 1905 Protein_2813 cadmium-translocating P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2957783..2976703 18920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(28-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20370.75 Da        Isoelectric Point: 4.6975

>T138795 WP_070352248.1 NZ_CP043474:2959360-2959920 [Mycobacterium grossiae]
VSNGLDEELVQRIDARGTVQWSGTCFRYTGAHREPLSGEGARRFGGRWNPPLLFSAIYLADSAQACMVEVERAAQAASTT
PEQMLQARYRLHTIQATDMAVLDLTTAEARDAVGLEDDDIYGDDWSACQAVGHAAWFLHVQGVLVPAAGGVGLVITAYEQ
RTRPGQLQISHSEDLTPTLYRQLRDP

Download         Length: 561 bp

>T138795 NZ_CP043474:2959360-2959920 [Mycobacterium grossiae]
GTGAGCAATGGGCTCGACGAAGAGCTGGTGCAGCGCATCGATGCGCGTGGCACCGTGCAGTGGTCGGGCACCTGCTTCCG
TTACACCGGCGCCCATCGTGAGCCGTTGTCGGGGGAGGGGGCGCGCAGATTCGGCGGGAGATGGAATCCGCCATTGCTGT
TCTCGGCGATTTATCTGGCCGATTCCGCGCAAGCGTGCATGGTTGAAGTGGAACGCGCCGCCCAGGCCGCATCGACGACA
CCCGAGCAGATGCTCCAAGCCCGCTACCGGCTGCACACCATTCAAGCGACCGACATGGCGGTTCTGGATCTGACCACCGC
CGAAGCGCGTGACGCGGTGGGGCTCGAAGACGACGACATCTACGGCGACGATTGGTCGGCCTGCCAAGCGGTGGGCCATG
CCGCGTGGTTTCTTCACGTGCAAGGAGTACTTGTGCCGGCGGCCGGTGGAGTCGGCCTGGTCATCACCGCCTACGAACAG
CGCACCCGCCCTGGCCAACTCCAAATCAGCCACAGCGAAGACCTGACACCAACCCTGTACCGACAACTACGTGACCCCTA
A

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12254.03 Da        Isoelectric Point: 5.0916

>AT138795 WP_070352249.1 NZ_CP043474:2959022-2959363 [Mycobacterium grossiae]
MGTSALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLAHGKPADLVRDGEYQRVLALIDAMAEGIFV

Download         Length: 342 bp

>AT138795 NZ_CP058225:47333-47584 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTACCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E8Q7U4

Antitoxin

Source ID Structure
AlphaFold DB A0A1E8Q7J7

References