Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2679677..2681277 Replicon plasmid unnamed1
Accession NZ_CP043441
Organism Cupriavidus campinensis strain MJ1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FZF10_RS30700 Protein ID WP_187645242.1
Coordinates 2679952..2681277 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FZF10_RS30695 Protein ID WP_149139194.1
Coordinates 2679677..2679952 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF10_RS30665 2674987..2675442 + 456 WP_144197175.1 hotdog family protein -
FZF10_RS30670 2675439..2676170 + 732 WP_144197106.1 3-oxoacyl-ACP reductase FabG -
FZF10_RS30675 2676167..2677396 + 1230 WP_149139191.1 beta-ketoacyl-ACP synthase -
FZF10_RS30680 2677479..2677934 + 456 WP_144197108.1 excinuclease ATPase subunit -
FZF10_RS30685 2677983..2678675 + 693 WP_149139192.1 4'-phosphopantetheinyl transferase superfamily protein -
FZF10_RS30690 2678699..2679433 - 735 WP_149139193.1 IclR family transcriptional regulator -
FZF10_RS30695 2679677..2679952 + 276 WP_149139194.1 helix-turn-helix domain-containing protein Antitoxin
FZF10_RS30700 2679952..2681277 + 1326 WP_187645242.1 type II toxin-antitoxin system HipA family toxin Toxin
FZF10_RS30705 2681638..2681904 + 267 WP_149139429.1 isochorismatase -
FZF10_RS30710 2681897..2682118 + 222 WP_092299836.1 translation initiation factor IF-1 -
FZF10_RS30715 2682156..2682419 + 264 WP_149139195.1 translation initiation factor 1 -
FZF10_RS30720 2682432..2683352 - 921 WP_149139196.1 2-dehydropantoate 2-reductase -
FZF10_RS30725 2683443..2684156 - 714 WP_144197114.1 GntR family transcriptional regulator -
FZF10_RS30730 2684259..2685080 - 822 WP_144197115.1 ABC transporter ATP-binding protein -
FZF10_RS30735 2685083..2685934 - 852 WP_149139197.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - plc / adeG / acrB / hcp/tssD / vipB/tssC / katA / hsiC1/vipB / hsiB1/vipA / motA / cheA / cheW / cheB / cheY / flhA / flgC / flgG / flgI / fliI / ddhA 1..2786414 2786414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-65)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 48344.08 Da        Isoelectric Point: 7.0158

>T138791 WP_187645242.1 NZ_CP043441:2679952-2681277 [Cupriavidus campinensis]
MGRRPLRRQLGVWMNGHFTGVWAQGSEGETFHYASRWIHSAQGRPLSLSMPFRSDNAPYRGRVVTDYFDNLLPDSDAIRR
RLAQRYRTRGTGPFDLLTALGRDCVGALQLLPEGEVPEALRTIEGSPADDAHIARLLRDTTSASPLGQHGDDADLRLSIA
GAQEKTALLRQDGQWFIPHGSTPTTHILKLPLGLVGNMRADMRTSVENEWLCAQLVEAFGLPIAACEMAMFEDQKALVVE
RFDRRVAPDGEWILRLPQEDFCQAMGLSPLAKYQADGGPGIADIMAILAGSDAREADRRNFFKTQILFWMLAATDGHAKN
FSLSIGPGGRYWATPLYDVLSAHPIVGGGANQLAMQKARMAMAVRGSQNYYRLAQIQRRHWIAQGRQVGLPEADVESIIA
ELVAAVDPALAAVAARLPGDFPQDVAGAVFDGIRAQGNKLL

Download         Length: 1326 bp

>T138791 NZ_CP058223:c4224451-4224074 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGTTGTC
CCGGTTACTGGACCAGCATTACGGCCTTACGCTGGATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGGCATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10114.61 Da        Isoelectric Point: 9.9661

>AT138791 WP_149139194.1 NZ_CP043441:2679677-2679952 [Cupriavidus campinensis]
MYPIRIISQLRPILQGFRKSRGLTQAQLAARLGVSQQTYARLEANPARVSVERLHAVLQALDVEMLLSADGDDDNRGGGA
MLRQPPPHEPW

Download         Length: 276 bp

>AT138791 NZ_CP058223:c4224908-4224540 [Escherichia coli]
GTGTCAGACAAGCTCCATGAGACAAATTATCCCGACGATCATAACGACCGCATCTGGTGGGGACTCCCCTGCACGGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCAACCGTGCCGGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCTATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References