Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3073972..3074651 Replicon chromosome
Accession NZ_CP043440
Organism Cupriavidus campinensis strain MJ1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FZF10_RS16160 Protein ID WP_149137139.1
Coordinates 3074223..3074651 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FZF10_RS16155 Protein ID WP_144202032.1
Coordinates 3073972..3074226 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF10_RS16125 3069435..3069746 + 312 WP_092300146.1 thiosulfate oxidation carrier complex protein SoxZ -
FZF10_RS16130 3069769..3070242 + 474 WP_144202061.1 DsrE family protein -
FZF10_RS16135 3070374..3071213 + 840 WP_149137137.1 sulfur oxidation c-type cytochrome SoxA -
FZF10_RS16140 3071231..3071926 + 696 WP_149137138.1 sulfur oxidation c-type cytochrome SoxX -
FZF10_RS16145 3071945..3073665 + 1721 Protein_2785 thiosulfohydrolase SoxB -
FZF10_RS16155 3073972..3074226 + 255 WP_144202032.1 Arc family DNA-binding protein Antitoxin
FZF10_RS16160 3074223..3074651 + 429 WP_149137139.1 type II toxin-antitoxin system VapC family toxin Toxin
FZF10_RS16165 3074648..3075610 + 963 WP_187645101.1 cation diffusion facilitator family transporter -
FZF10_RS16170 3075566..3076195 - 630 WP_149137140.1 LysE family translocator -
FZF10_RS16175 3076602..3077228 - 627 WP_149137141.1 DNA-3-methyladenine glycosylase I -
FZF10_RS16180 3077392..3078702 - 1311 WP_149137142.1 MFS transporter -
FZF10_RS16185 3078751..3079068 - 318 WP_149137143.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(6-46)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15108.37 Da        Isoelectric Point: 5.7065

>T138788 WP_149137139.1 NZ_CP043440:3074223-3074651 [Cupriavidus campinensis]
MIVLDTNVVSEAMKPEPNPAVRAWLNAQVAETLYLSSVTLAELLFGIGALPEGRRKHGLSETLDGLLALFGDRVLMFDTG
AARHYAELAVKARLAGKGFPTPDGYIGAIAASRGYIVATRDTAPFEAAGLTVINPWNSTQIP

Download         Length: 429 bp

>T138788 NZ_CP058223:3862244-3862351 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9491.79 Da        Isoelectric Point: 6.4732

>AT138788 WP_144202032.1 NZ_CP043440:3073972-3074226 [Cupriavidus campinensis]
MPMLTVRNVPDEVHRALRMRAAEHGRSTEAEVREILERAVKSEQRVRMGDALAALGQRAGLTNDDFAVFDTQRDKAPAEP
MKFE

Download         Length: 255 bp

>AT138788 NZ_CP058223:c3862191-3862130 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References