Detailed information of TA system TA138788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3073972..3074651
• Replicon: chromosome
• Accession: NZ_CP043440
• Organism: Cupriavidus campinensis strain MJ1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FZF10_RS16160
• Protein ID: WP_149137139.1
• Coordinates: 3074223..3074651 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FZF10_RS16155
• Protein ID: WP_144202032.1
• Coordinates: 3073972..3074226 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZF10_RS16125	3069435..3069746	+	312	WP_092300146.1	thiosulfate oxidation carrier complex protein SoxZ	-
FZF10_RS16130	3069769..3070242	+	474	WP_144202061.1	DsrE family protein	-
FZF10_RS16135	3070374..3071213	+	840	WP_149137137.1	sulfur oxidation c-type cytochrome SoxA	-
FZF10_RS16140	3071231..3071926	+	696	WP_149137138.1	sulfur oxidation c-type cytochrome SoxX	-
FZF10_RS16145	3071945..3073665	+	1721	Protein_2785	thiosulfohydrolase SoxB	-
FZF10_RS16155	3073972..3074226	+	255	WP_144202032.1	Arc family DNA-binding protein	Antitoxin
FZF10_RS16160	3074223..3074651	+	429	WP_149137139.1	type II toxin-antitoxin system VapC family toxin	Toxin
FZF10_RS16165	3074648..3075610	+	963	WP_187645101.1	cation diffusion facilitator family transporter	-
FZF10_RS16170	3075566..3076195	-	630	WP_149137140.1	LysE family translocator	-
FZF10_RS16175	3076602..3077228	-	627	WP_149137141.1	DNA-3-methyladenine glycosylase I	-
FZF10_RS16180	3077392..3078702	-	1311	WP_149137142.1	MFS transporter	-
FZF10_RS16185	3078751..3079068	-	318	WP_149137143.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Arc-like DNA binding domain (6-46)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15108.37 Da
• Isoelectric Point: 5.7065

>T138788 WP_149137139.1 NZ_CP043440:3074223-3074651 [Cupriavidus campinensis]
MIVLDTNVVSEAMKPEPNPAVRAWLNAQVAETLYLSSVTLAELLFGIGALPEGRRKHGLSETLDGLLALFGDRVLMFDTG
AARHYAELAVKARLAGKGFPTPDGYIGAIAASRGYIVATRDTAPFEAAGLTVINPWNSTQIP

Nucleotide

• Length: 429 bp

>T138788 NZ_CP058223:3862244-3862351 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9491.79 Da
• Isoelectric Point: 6.4732

>AT138788 WP_144202032.1 NZ_CP043440:3073972-3074226 [Cupriavidus campinensis]
MPMLTVRNVPDEVHRALRMRAAEHGRSTEAEVREILERAVKSEQRVRMGDALAALGQRAGLTNDDFAVFDTQRDKAPAEP
MKFE

Nucleotide

• Length: 255 bp

>AT138788 NZ_CP058223:c3862191-3862130 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT