Detailed information of TA system TA138786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 347030..347553
• Replicon: chromosome
• Accession: NZ_CP043440
• Organism: Cupriavidus campinensis strain MJ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FZF10_RS03640
• Protein ID: WP_149135464.1
• Coordinates: 347293..347553 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FZF10_RS03635
• Protein ID: WP_144198136.1
• Coordinates: 347030..347296 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZF10_RS03620	342788..344289	-	1502	Protein_321	tripartite tricarboxylate transporter permease	-
FZF10_RS03625	344303..344764	-	462	WP_149135463.1	tripartite tricarboxylate transporter TctB family protein	-
FZF10_RS03630	345170..346939	+	1770	Protein_323	potassium/proton antiporter	-
FZF10_RS03635	347030..347296	+	267	WP_144198136.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FZF10_RS03640	347293..347553	+	261	WP_149135464.1	Txe/YoeB family addiction module toxin	Toxin
FZF10_RS03645	347583..348617	-	1035	WP_149135465.1	tripartite tricarboxylate transporter substrate binding protein	-
FZF10_RS03650	348649..349104	-	456	WP_149135466.1	DUF2214 family protein	-
FZF10_RS03655	349183..350403	-	1221	WP_149135467.1	CoA transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10248.63 Da
• Isoelectric Point: 7.9846

>T138786 WP_149135464.1 NZ_CP043440:347293-347553 [Cupriavidus campinensis]
MTRKVLFTPDAWEDYVYWQGQDRKTLKRINQLIKEVQRTPFEGIGKPEPLVGNLTGFWSRRIDDANRLVYEATEDQVNIV
ACRYHY

Nucleotide

• Length: 261 bp

>T138786 NZ_CP043440:347293-347553 [Cupriavidus campinensis]
ATGACCCGCAAGGTCTTATTCACGCCGGATGCATGGGAAGACTATGTGTATTGGCAGGGTCAGGATCGTAAAACCCTGAA
ACGCATCAATCAGTTGATCAAGGAAGTGCAACGCACGCCGTTCGAGGGGATTGGCAAGCCCGAGCCTTTGGTCGGCAACC
TCACCGGCTTCTGGTCGAGGCGGATCGATGATGCGAACCGCCTCGTCTATGAAGCCACGGAAGACCAGGTCAACATCGTG
GCTTGCCGCTATCACTATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9799.89 Da
• Isoelectric Point: 5.0967

>AT138786 WP_144198136.1 NZ_CP043440:347030-347296 [Cupriavidus campinensis]
MRTVHFSDARNNLKAVIDQTIDDADVTLITRRDAPNAVLMSQDLYESIAETLHLLRSRANADRLASSIAQLRGGNTKERA
LHEPEGDE

Nucleotide

• Length: 267 bp

>AT138786 NZ_CP043440:347030-347296 [Cupriavidus campinensis]
ATGCGCACCGTCCACTTCTCGGATGCCCGGAACAATCTGAAGGCAGTAATCGATCAGACCATCGACGACGCCGACGTCAC
GCTAATTACGCGCCGTGACGCGCCGAACGCCGTGCTCATGTCTCAGGATCTCTACGAGAGCATCGCCGAAACCCTGCATC
TTCTCCGTTCGCGTGCCAATGCAGACCGTCTGGCCAGCTCGATTGCGCAATTGCGTGGAGGCAACACGAAGGAGCGCGCG
CTCCATGAGCCCGAGGGCGATGAATGA