Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4548141..4548757 Replicon chromosome
Accession NZ_CP043438
Organism Enterobacter sp. LU1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FZF21_RS21720 Protein ID WP_017382676.1
Coordinates 4548141..4548512 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag FZF21_RS21725 Protein ID WP_015569912.1
Coordinates 4548515..4548757 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF21_RS21705 4545641..4546543 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
FZF21_RS21710 4546540..4547175 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
FZF21_RS21715 4547172..4548101 + 930 WP_149121140.1 formate dehydrogenase accessory protein FdhE -
FZF21_RS21720 4548141..4548512 - 372 WP_017382676.1 type II toxin-antitoxin system VapC family toxin Toxin
FZF21_RS21725 4548515..4548757 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
FZF21_RS21730 4548956..4549876 + 921 WP_045142559.1 alpha/beta hydrolase -
FZF21_RS21735 4549885..4550826 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
FZF21_RS21740 4550871..4551308 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
FZF21_RS21745 4551305..4552186 - 882 WP_003861949.1 virulence factor BrkB family protein -
FZF21_RS21750 4552180..4552779 - 600 WP_017694048.1 glucose-1-phosphatase -
FZF21_RS21755 4552898..4553698 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13737.88 Da        Isoelectric Point: 6.4882

>T138784 WP_017382676.1 NZ_CP043438:c4548512-4548141 [Enterobacter sp. LU1]
MEHMAVFDTNILIDLFNNRIEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T138784 NZ_CP058223:3228783-3228886 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT138784 WP_015569912.1 NZ_CP043438:c4548757-4548515 [Enterobacter sp. LU1]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT138784 NZ_CP043438:c4548757-4548515 [Enterobacter sp. LU1]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATTGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAGCCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References