Detailed information of TA system TA138783

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3737891..3738548
• Replicon: chromosome
• Accession: NZ_CP043438
• Organism: Enterobacter sp. LU1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FZF21_RS17860
• Protein ID: WP_047738334.1
• Coordinates: 3737891..3738301 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: FZF21_RS17865
• Protein ID: WP_003863437.1
• Coordinates: 3738282..3738548 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZF21_RS17840	3733889..3735622	-	1734	WP_017382886.1	single-stranded-DNA-specific exonuclease RecJ	-
FZF21_RS17845	3735628..3736341	-	714	WP_015571792.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FZF21_RS17850	3736370..3737266	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
FZF21_RS17855	3737368..3737889	+	522	WP_015571793.1	flavodoxin FldB	-
FZF21_RS17860	3737891..3738301	-	411	WP_047738334.1	protein YgfX	Toxin
FZF21_RS17865	3738282..3738548	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
FZF21_RS17870	3738843..3739823	+	981	WP_017692714.1	tRNA-modifying protein YgfZ	-
FZF21_RS17875	3739935..3740594	-	660	WP_003863433.1	hemolysin III family protein	-
FZF21_RS17880	3740861..3741592	+	732	WP_015571796.1	MurR/RpiR family transcriptional regulator	-
FZF21_RS17885	3741709..3743142	+	1434	WP_017382891.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16337.20 Da
• Isoelectric Point: 11.4775

>T138783 WP_047738334.1 NZ_CP043438:c3738301-3737891 [Enterobacter sp. LU1]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPSEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T138783 NZ_CP058223:c3035400-3035026 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT138783 WP_003863437.1 NZ_CP043438:c3738548-3738282 [Enterobacter sp. LU1]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT138783 NZ_CP043438:c3738548-3738282 [Enterobacter sp. LU1]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5