Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2283366..2284105 Replicon chromosome
Accession NZ_CP043438
Organism Enterobacter sp. LU1

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag FZF21_RS11020 Protein ID WP_003857133.1
Coordinates 2283366..2283851 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag FZF21_RS11025 Protein ID WP_003857131.1
Coordinates 2283839..2284105 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF21_RS11000 2279519..2280277 - 759 WP_023296628.1 trans-aconitate 2-methyltransferase -
FZF21_RS11005 2280362..2280946 - 585 WP_149121326.1 GDP-mannose pyrophosphatase -
FZF21_RS11010 2281033..2281791 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
FZF21_RS11015 2281896..2283188 + 1293 WP_045349604.1 glycoside hydrolase -
FZF21_RS11020 2283366..2283851 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
FZF21_RS11025 2283839..2284105 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
FZF21_RS11030 2284169..2285098 - 930 WP_047726560.1 LysR family transcriptional regulator -
FZF21_RS11035 2285228..2286610 + 1383 WP_149121325.1 MFS transporter -
FZF21_RS11040 2286632..2287627 - 996 WP_017382342.1 DUF2891 domain-containing protein -
FZF21_RS11045 2287637..2288623 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T138773 WP_003857133.1 NZ_CP043438:c2283851-2283366 [Enterobacter sp. LU1]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T138773 NZ_CP058222:c5020745-5020434 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT138773 WP_003857131.1 NZ_CP043438:c2284105-2283839 [Enterobacter sp. LU1]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT138773 NZ_CP058222:c5020433-5020143 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References