Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1070588..1071208 Replicon chromosome
Accession NZ_CP043438
Organism Enterobacter sp. LU1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FZF21_RS05045 Protein ID WP_015571250.1
Coordinates 1070588..1070806 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FZF21_RS05050 Protein ID WP_006809850.1
Coordinates 1070834..1071208 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF21_RS05015 1066600..1066860 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FZF21_RS05020 1066863..1067003 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FZF21_RS05025 1067000..1067710 - 711 WP_047738029.1 GNAT family N-acetyltransferase -
FZF21_RS05030 1067812..1069272 + 1461 WP_033486652.1 PLP-dependent aminotransferase family protein -
FZF21_RS05035 1069244..1069711 - 468 WP_015571252.1 extracytoplasmic function sigma factor YlaC -
FZF21_RS05040 1069828..1070379 - 552 WP_015571251.1 maltose O-acetyltransferase -
FZF21_RS05045 1070588..1070806 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FZF21_RS05050 1070834..1071208 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FZF21_RS05055 1071719..1074865 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FZF21_RS05060 1074888..1076081 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T138770 WP_015571250.1 NZ_CP043438:c1070806-1070588 [Enterobacter sp. LU1]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T138770 NZ_CP058222:4457335-4457676 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT138770 WP_006809850.1 NZ_CP043438:c1071208-1070834 [Enterobacter sp. LU1]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT138770 NZ_CP058222:c4457340-4457264 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References