Detailed information of TA system TA138769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 608751..609327
• Replicon: chromosome
• Accession: NZ_CP043438
• Organism: Enterobacter sp. LU1

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: A0A800YKM1
• Locus tag: FZF21_RS02890
• Protein ID: WP_015572580.1
• Coordinates: 608751..609038 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: A0A801DSF4
• Locus tag: FZF21_RS02895
• Protein ID: WP_017694570.1
• Coordinates: 609025..609327 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZF21_RS02865	603844..604563	+	720	WP_047062293.1	winged helix-turn-helix domain-containing protein	-
FZF21_RS02870	604713..605183	+	471	WP_023303035.1	MarR family transcriptional regulator	-
FZF21_RS02875	605180..606247	+	1068	WP_026094404.1	HlyD family secretion protein	-
FZF21_RS02880	606237..607313	+	1077	WP_015572578.1	DUF2955 domain-containing protein	-
FZF21_RS02885	607310..608581	-	1272	WP_015572579.1	DUF445 domain-containing protein	-
FZF21_RS02890	608751..609038	+	288	WP_015572580.1	BrnT family toxin	Toxin
FZF21_RS02895	609025..609327	+	303	WP_017694570.1	BrnA antitoxin family protein	Antitoxin
FZF21_RS02900	609356..609994	-	639	WP_047736941.1	LysE family translocator	-
FZF21_RS02905	610033..610785	-	753	WP_017383861.1	AraC family transcriptional regulator	-
FZF21_RS02910	610939..612309	+	1371	WP_015572583.1	NAD-dependent succinate-semialdehyde dehydrogenase	-
FZF21_RS02915	612490..613035	-	546	WP_006810254.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (32-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11296.81 Da
• Isoelectric Point: 7.3587

>T138769 WP_015572580.1 NZ_CP043438:608751-609038 [Enterobacter sp. LU1]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Nucleotide

• Length: 288 bp

>T138769 NZ_CP058222:4374731-4374883 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11482.13 Da
• Isoelectric Point: 10.4094

>AT138769 WP_017694570.1 NZ_CP043438:609025-609327 [Enterobacter sp. LU1]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT138769 NZ_CP043438:609025-609327 [Enterobacter sp. LU1]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA