Detailed information of TA system TA138768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 303949..304545
• Replicon: chromosome
• Accession: NZ_CP043438
• Organism: Enterobacter sp. LU1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: FZF21_RS01440
• Protein ID: WP_047736653.1
• Coordinates: 304243..304545 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A927HL08
• Locus tag: FZF21_RS01435
• Protein ID: WP_023295755.1
• Coordinates: 303949..304236 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZF21_RS01430	302321..303952	+	1632	WP_003860350.1	Na/Pi cotransporter family protein	-
FZF21_RS01435	303949..304236	-	288	WP_023295755.1	putative addiction module antidote protein	Antitoxin
FZF21_RS01440	304243..304545	-	303	WP_047736653.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FZF21_RS01445	304743..305615	+	873	WP_003860347.1	23S rRNA pseudouridine(2604) synthase RluF	-
FZF21_RS01450	305616..305888	-	273	WP_017382612.1	DUF3811 domain-containing protein	-
FZF21_RS01455	305939..306883	-	945	WP_015570166.1	ketopantoate/pantoate/pantothenate transporter PanS	-
FZF21_RS01460	306977..308326	-	1350	WP_006810501.1	lysine-sensitive aspartokinase 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-93)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11485.28 Da
• Isoelectric Point: 10.3736

>T138768 WP_047736653.1 NZ_CP043438:c304545-304243 [Enterobacter sp. LU1]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNFIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Nucleotide

• Length: 303 bp

>T138768 NZ_CP058222:c4337813-4337499 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10101.59 Da
• Isoelectric Point: 5.7807

>AT138768 WP_023295755.1 NZ_CP043438:c304236-303949 [Enterobacter sp. LU1]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Nucleotide

• Length: 288 bp

>AT138768 NZ_CP058222:c4338049-4337816 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG