Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 5572..6487 Replicon plasmid p3226
Accession NZ_CP043436
Organism Campylobacter fetus subsp. venerealis NCTC 10354

Toxin (Protein)


Gene name Fic Uniprot ID A0A974RKV0
Locus tag CFVT_RS09655 Protein ID WP_024305403.1
Coordinates 5572..6258 (-) Length 229 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A974MUU2
Locus tag CFVT_RS09660 Protein ID WP_002850985.1
Coordinates 6251..6487 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFVT_RS09625 1986..2195 - 210 WP_002850993.1 hypothetical protein -
CFVT_RS09630 2199..2885 - 687 WP_002850991.1 AAA family ATPase -
CFVT_RS09635 2996..3367 - 372 WP_002850989.1 hypothetical protein -
CFVT_RS09640 3364..3654 - 291 WP_051945896.1 S26 family signal peptidase -
CFVT_RS09645 3758..4213 + 456 WP_010404250.1 IS200/IS605 family transposase -
CFVT_RS09650 4191..5291 + 1101 WP_010404252.1 transposase -
CFVT_RS09655 5572..6258 - 687 WP_024305403.1 Fic family protein Toxin
CFVT_RS09660 6251..6487 - 237 WP_002850985.1 hypothetical protein Antitoxin
CFVT_RS09665 6604..7311 - 708 WP_002850984.1 conjugal transfer protein TraL -
CFVT_RS09670 7308..9149 - 1842 WP_002850983.1 type IV secretory system conjugative DNA transfer family protein -
CFVT_RS09675 9159..10607 - 1449 WP_080723873.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..27915 27915
- flank IS/Tn - - 3758..4213 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 229 a.a.        Molecular weight: 25978.99 Da        Isoelectric Point: 10.0098

>T138766 WP_024305403.1 NZ_CP043436:c6258-5572 [Campylobacter fetus subsp. venerealis NCTC 10354]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFKDVYTWA
GKDRMEVGLHGNFGKYAPNGTITNFVPGKDLNATAQQIFTWLKEDNYLTNSKDLNDFAKNLAEFARNLNALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLIPKDKMIMASVEASQLKLGKLEAIIKTNLKSFKQNLEKENTLGLSLC

Download         Length: 687 bp

>T138766 NZ_CP058222:3833190-3833408 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9006.20 Da        Isoelectric Point: 4.3316

>AT138766 WP_002850985.1 NZ_CP043436:c6487-6251 [Campylobacter fetus subsp. venerealis NCTC 10354]
MTYPEVHSLEESLAILKKYKDDLTKEQYDGIKSIICGHAIEDMFANERDIIDMIKIAKNEANADEIIAEYKKEWGVND

Download         Length: 237 bp

>AT138766 NZ_CP043436:c6487-6251 [Campylobacter fetus subsp. venerealis NCTC 10354]
ATGACATATCCAGAAGTACATAGCCTAGAAGAGAGTTTAGCAATACTTAAAAAATACAAAGATGATTTAACTAAAGAGCA
ATACGATGGAATTAAATCTATAATTTGCGGACACGCTATTGAAGATATGTTTGCAAATGAAAGAGACATTATTGATATGA
TAAAAATTGCAAAAAATGAAGCAAATGCCGATGAAATAATCGCCGAATATAAAAAAGAGTGGGGAGTAAATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References