Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | fic-relB/Fic(toxin) |
| Location | 1225896..1227652 | Replicon | chromosome |
| Accession | NZ_CP043435 | ||
| Organism | Campylobacter fetus subsp. venerealis NCTC 10354 | ||
Toxin (Protein)
| Gene name | Fic | Uniprot ID | C5H2Y4 |
| Locus tag | CFVT_RS06190 | Protein ID | WP_002850956.1 |
| Coordinates | 1225896..1226816 (-) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | Fic | Uniprot ID | B2CG46 |
| Locus tag | CFVT_RS06195 | Protein ID | WP_002850958.1 |
| Coordinates | 1226816..1227652 (-) | Length | 279 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CFVT_RS06155 | 1221095..1221355 | - | 261 | WP_002850932.1 | hypothetical protein | - |
| CFVT_RS09825 | 1221352..1221519 | - | 168 | WP_002850934.1 | hypothetical protein | - |
| CFVT_RS06160 | 1221597..1222472 | - | 876 | WP_025370363.1 | PcfJ domain-containing protein | - |
| CFVT_RS06165 | 1222643..1223035 | - | 393 | WP_025370364.1 | hypothetical protein | - |
| CFVT_RS06170 | 1223177..1223404 | - | 228 | WP_025370365.1 | hypothetical protein | - |
| CFVT_RS06175 | 1223721..1224284 | + | 564 | WP_035148446.1 | hypothetical protein | - |
| CFVT_RS06180 | 1224281..1225618 | + | 1338 | WP_035148452.1 | hypothetical protein | - |
| CFVT_RS06185 | 1225627..1225896 | - | 270 | WP_035148454.1 | hypothetical protein | - |
| CFVT_RS06190 | 1225896..1226816 | - | 921 | WP_002850956.1 | Fic family protein | Toxin |
| CFVT_RS06195 | 1226816..1227652 | - | 837 | WP_002850958.1 | Fic family protein | Antitoxin |
| CFVT_RS06200 | 1227656..1227958 | - | 303 | WP_080582791.1 | DUF86 domain-containing protein | - |
| CFVT_RS06205 | 1228080..1228391 | - | 312 | WP_002850963.1 | nucleotidyltransferase domain-containing protein | - |
| CFVT_RS06210 | 1228459..1229121 | - | 663 | WP_002850964.1 | AAA family ATPase | - |
| CFVT_RS06215 | 1229146..1229463 | - | 318 | WP_010400644.1 | hypothetical protein | - |
| CFVT_RS06220 | 1229531..1230241 | - | 711 | WP_002850968.1 | hypothetical protein | - |
| CFVT_RS06225 | 1230444..1230659 | - | 216 | WP_002850970.1 | hypothetical protein | - |
| CFVT_RS06230 | 1230656..1230910 | - | 255 | WP_010400630.1 | hypothetical protein | - |
| CFVT_RS06235 | 1230907..1232127 | - | 1221 | WP_002850972.1 | hypothetical protein | - |
| CFVT_RS06240 | 1232124..1232621 | - | 498 | WP_002850973.1 | lytic transglycosylase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1214236..1255953 | 41717 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 35445.26 Da Isoelectric Point: 9.2339
>T138765 WP_002850956.1 NZ_CP043435:c1226816-1225896 [Campylobacter fetus subsp. venerealis NCTC 10354]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKLLPNSPKGHKSEKSVLSRLGAAYDKKVQSGAIKQPQISKKSKEKER
Download Length: 921 bp
>T138765 NZ_CP058222:2879139-2879246 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA
Antitoxin
Download Length: 279 a.a. Molecular weight: 31851.33 Da Isoelectric Point: 8.5962
>AT138765 WP_002850958.1 NZ_CP043435:c1227652-1226816 [Campylobacter fetus subsp. venerealis NCTC 10354]
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQILPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER
Download Length: 837 bp
>AT138765 NZ_CP058222:c2879083-2879022 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D7L3Y5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7D7Q668 |