Detailed information of TA system TA138764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 286544..287055
• Replicon: chromosome
• Accession: NZ_CP043430
• Organism: Microbacterium sp. 1S1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FY549_RS01485
• Protein ID: WP_149083510.1
• Coordinates: 286789..287055 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FY549_RS01480
• Protein ID: WP_149083509.1
• Coordinates: 286544..286792 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY549_RS01475	281913..286496	+	4584	WP_149083508.1	ATP-dependent helicase	-
FY549_RS01480	286544..286792	+	249	WP_149083509.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FY549_RS01485	286789..287055	+	267	WP_149083510.1	Txe/YoeB family addiction module toxin	Toxin
FY549_RS01490	287074..287862	+	789	WP_149083511.1	EI24 domain-containing protein	-
FY549_RS01495	287862..288635	+	774	WP_149083512.1	Fpg/Nei family DNA glycosylase	-
FY549_RS01500	288717..289124	+	408	WP_149083513.1	transferase	-
FY549_RS01505	289131..289791	-	661	Protein_287	response regulator transcription factor	-
FY549_RS01510	289784..291010	-	1227	WP_149083514.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-66)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10507.93 Da
• Isoelectric Point: 7.3990

>T138764 WP_149083510.1 NZ_CP043430:286789-287055 [Microbacterium sp. 1S1]
MTTRLLVWTPEGWEDYVYWQTEDRRTLKRIDLLIADTLRDDPFQGIGKPEPLKHALAGAWSRRIDEAHRLVYTATDRHVT
ILQARYHY

Nucleotide

• Length: 267 bp

>T138764 NZ_CP058222:2640188-2640466 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8991.98 Da
• Isoelectric Point: 4.4665

>AT138764 WP_149083509.1 NZ_CP043430:286544-286792 [Microbacterium sp. 1S1]
MAITTSEARRDLFGLIERVNLDHSEVEITSRRGSAVLMSKAEYDSLVETSYLLRSPANAQRLLSALAAGRDGDVSEHDLD
EA

Nucleotide

• Length: 249 bp

>AT138764 NZ_CP058222:2640466-2640750 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA