Detailed information of TA system TA138763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1407871..1409002
• Replicon: chromosome
• Accession: NZ_CP043428
• Organism: Campylobacter volucris strain LMG 24380

Toxin (Protein)

• Gene name: panT
• Uniprot ID: A0A5C8KXZ5
• Locus tag: CVOLT_RS07295
• Protein ID: WP_039666119.1
• Coordinates: 1407871..1408584 (-)
• Length: 238 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: CVOLT_RS07300
• Protein ID: WP_039666120.1
• Coordinates: 1408574..1409002 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVOLT_RS07275	1403229..1403879	-	651	WP_039666115.1	NAD-independent L-lactate dehydrogenase subunit	-
CVOLT_RS07280	1403872..1405287	-	1416	WP_039666116.1	iron-sulfur cluster-binding protein	-
CVOLT_RS07285	1405284..1406021	-	738	WP_039666117.1	NAD-independent L-lactate dehydrogenase, oxidoreductase subunit	-
CVOLT_RS07290	1406030..1407685	-	1656	WP_039666118.1	L-lactate permease	-
CVOLT_RS07295	1407871..1408584	-	714	WP_039666119.1	hypothetical protein	Toxin
CVOLT_RS07300	1408574..1409002	-	429	WP_039666120.1	DUF4065 domain-containing protein	Antitoxin
CVOLT_RS07305	1409143..1410942	-	1800	WP_039666121.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-117)

Sequences

Toxin

Protein

• Length: 238 a.a.
• Molecular weight: 28025.80 Da
• Isoelectric Point: 6.6867

>T138763 WP_039666119.1 NZ_CP043428:c1408584-1407871 [Campylobacter volucris]
MSFKKEHKELKVIIEKIYNEQSLESSCDDIVEKLITIYKTEYKHKYSELTTIILNITKSDREQDLMTLAQNVRMLEEKLD
NKTCDECIKEKIKDFYDHINLECVRLQDSDGKIKKIKDEYNELYKNYNNIKDNLSKQQTQYITILGIFASIVLTFVSGLV
FSTSVLSNIDKVSIFRLIFTMAFIAFFVGNILYSLFAFLLKISSIYSCKSNIYIYVFNLIIFLIMLIDFCFYLYCFY

Nucleotide

• Length: 714 bp

>T138763 NZ_CP058222:2602605-2603927 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGAATTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 16908.10 Da
• Isoelectric Point: 5.3615

>AT138763 WP_039666120.1 NZ_CP043428:c1409002-1408574 [Campylobacter volucris]
MVNALDLAKYILYKSDKDLSNLELQKTLYFTELDYIKKFDKHLINDDFEAWKYGPVARDVYCEYRNYGANSIDKPNDEIQ
LNLDNDELEIINNSIKKCNKQSYWILVEKSHRKGGAWEQSFKENKKEVINKELIKQEAKNEF

Nucleotide

• Length: 429 bp

>AT138763 NZ_CP058222:2602339-2602605 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
GCAGAACAGCAAGATTTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A5C8KXZ5