Detailed information of TA system TA138762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2541427..2543045
• Replicon: chromosome
• Accession: NZ_CP043421
• Organism: Vibrio parahaemolyticus strain MVP1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: BSR23_RS12940
• Protein ID: WP_149144378.1
• Coordinates: 2541427..2542812 (-)
• Length: 462 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: BSR23_RS12945
• Protein ID: WP_017788886.1
• Coordinates: 2542806..2543045 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSR23_RS12915	2536512..2536976	+	465	WP_015296415.1	hotdog family protein	-
BSR23_RS12920	2536973..2537698	+	726	WP_015296414.1	3-oxoacyl-ACP reductase FabG	-
BSR23_RS12925	2537695..2538918	+	1224	WP_058964630.1	beta-ketoacyl-ACP synthase	-
BSR23_RS12930	2538964..2539554	-	591	WP_023624128.1	membrane lipoprotein lipid attachment site-containing protein	-
BSR23_RS12935	2539912..2541234	+	1323	WP_077673148.1	site-specific integrase	-
BSR23_RS12940	2541427..2542812	-	1386	WP_149144378.1	type II toxin-antitoxin system HipA family toxin	Toxin
BSR23_RS12945	2542806..2543045	-	240	WP_017788886.1	helix-turn-helix domain-containing protein	Antitoxin
BSR23_RS12950	2544896..2545204	+	309	WP_149144379.1	hypothetical protein	-
BSR23_RS12955	2546203..2547378	-	1176	WP_149144380.1	hypothetical protein	-
BSR23_RS12960	2547486..2547677	+	192	WP_025573512.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2539912..2549917	10005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-400)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-55)

Sequences

Toxin

Protein

• Length: 462 a.a.
• Molecular weight: 51779.65 Da
• Isoelectric Point: 9.0965

>T138762 WP_149144378.1 NZ_CP043421:c2542812-2541427 [Vibrio parahaemolyticus]
MVNRLHAYMNGVKVGVLEKRTNGAHVFTYDSGWVLAPNGRPISLSMPLRKDAYTGSEVINFFDNLLPDNQQIRDRIAARY
KADTKQPFDLLAKVGRDAVGAITLVPEGFDVDDHRTITAKALSEKELVRILKGYMEDAPLGMLKEEDDFRISIAGAQEKT
ALLFYDGRWMLPQGMTPTTHIIKLPIGEIVSQNNVIDLSASVDNELICMRLAKAFGIQTANCDIIRAGDVRALSVERFDR
KLSSDNSYYLRLPHEDFCQAKGIPSARKYEIDGGIGIEESIDILRYSYEINDTVTFARSQILFWLLAAIDGHGKNFSVSI
AASGRYQLAPLYDIISAHPLAGGRGLSERKIKMAMSLRGTSGRKWKWHQLQPRHFEDTFHTMNVPNIRREKVRLLLDEFE
STAMAVIDSVGNSLPTDINESVRDKIFNGVLKTVKKIQLTKKINQYLKKSFTVVQVIALLC

Nucleotide

• Length: 1386 bp

>T138762 NZ_CP058222:2310920-2311022 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8717.96 Da
• Isoelectric Point: 7.2036

>AT138762 WP_017788886.1 NZ_CP043421:c2543045-2542806 [Vibrio parahaemolyticus]
MLVNTPTALGNALREARKDNGLKQTDLGLRQATVSNFESNPEKSTIETLFKLLSINGLEMHIVPKGKHITETKGAVDEW

Nucleotide

• Length: 240 bp

>AT138762 NZ_CP058222:c2311060-2310792 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT