Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1492923..1493451 Replicon chromosome
Accession NZ_CP043421
Organism Vibrio parahaemolyticus strain MVP1

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag BSR23_RS07635 Protein ID WP_005377002.1
Coordinates 1492923..1493213 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag BSR23_RS07640 Protein ID WP_005377003.1
Coordinates 1493203..1493451 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSR23_RS07585 1487989..1488483 + 495 WP_031847825.1 GNAT family N-acetyltransferase -
BSR23_RS07590 1488633..1489415 + 783 WP_053319094.1 hypothetical protein -
BSR23_RS07595 1489572..1489946 + 375 WP_025553554.1 hypothetical protein -
BSR23_RS07600 1489955..1490068 + 114 WP_176092162.1 DUF3265 domain-containing protein -
BSR23_RS07605 1490109..1490735 + 627 WP_077673098.1 LysE family translocator -
BSR23_RS07610 1490741..1490854 + 114 WP_077673099.1 DUF3265 domain-containing protein -
BSR23_RS07615 1491578..1491703 + 126 WP_078232767.1 DUF3265 domain-containing protein -
BSR23_RS07620 1491743..1492114 + 372 WP_149144399.1 energy transducer TonB -
BSR23_RS07625 1492121..1492288 + 168 WP_187614825.1 DUF3265 domain-containing protein -
BSR23_RS07630 1492248..1492772 + 525 WP_176092139.1 GNAT family N-acetyltransferase -
BSR23_RS07635 1492923..1493213 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSR23_RS07640 1493203..1493451 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BSR23_RS07645 1493508..1493594 + 87 WP_080767783.1 DUF3265 domain-containing protein -
BSR23_RS07650 1494188..1494484 + 297 WP_052479024.1 helix-turn-helix domain-containing protein -
BSR23_RS07655 1494518..1494859 - 342 WP_077672855.1 type II toxin-antitoxin system RelE/ParE family toxin -
BSR23_RS07660 1495048..1495173 + 126 WP_077672995.1 DUF3265 domain-containing protein -
BSR23_RS07665 1495206..1495601 + 396 WP_077672980.1 ACT domain-containing protein -
BSR23_RS07670 1495868..1496107 + 240 WP_077672981.1 hypothetical protein -
BSR23_RS07680 1496243..1496515 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
BSR23_RS26780 1496490..1496636 + 147 WP_079740864.1 DUF3265 domain-containing protein -
BSR23_RS07695 1497137..1497583 + 447 WP_077672982.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD 1394121..1715920 321799
- inside Integron - - 1470987..1572878 101891


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T138761 WP_005377002.1 NZ_CP043421:c1493213-1492923 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T138761 NZ_CP058222:c2018729-2018355 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT138761 WP_005377003.1 NZ_CP043421:c1493451-1493203 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT138761 NZ_CP058222:c2019186-2018818 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References