Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1480748..1481313 | Replicon | chromosome |
| Accession | NZ_CP043421 | ||
| Organism | Vibrio parahaemolyticus strain MVP1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0H2MSY5 |
| Locus tag | BSR23_RS07510 | Protein ID | WP_015296903.1 |
| Coordinates | 1481026..1481313 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3BLE1 |
| Locus tag | BSR23_RS07505 | Protein ID | WP_000086647.1 |
| Coordinates | 1480748..1481029 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BSR23_RS07450 | 1476938..1477561 | + | 624 | WP_077672541.1 | hypothetical protein | - |
| BSR23_RS07455 | 1477703..1478197 | + | 495 | WP_077672542.1 | GNAT family N-acetyltransferase | - |
| BSR23_RS07470 | 1478743..1478856 | + | 114 | WP_176092163.1 | DUF3265 domain-containing protein | - |
| BSR23_RS07475 | 1478884..1479360 | + | 477 | WP_077672543.1 | GNAT family N-acetyltransferase | - |
| BSR23_RS07480 | 1479369..1479479 | + | 111 | WP_077672552.1 | DUF3265 domain-containing protein | - |
| BSR23_RS07485 | 1479511..1479969 | + | 459 | WP_077672544.1 | GNAT family N-acetyltransferase | - |
| BSR23_RS07490 | 1479985..1480137 | + | 153 | WP_077672545.1 | DUF3265 domain-containing protein | - |
| BSR23_RS07495 | 1480214..1480501 | + | 288 | WP_017817947.1 | hypothetical protein | - |
| BSR23_RS07505 | 1480748..1481029 | + | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| BSR23_RS07510 | 1481026..1481313 | + | 288 | WP_015296903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BSR23_RS07515 | 1481323..1481433 | + | 111 | WP_176092165.1 | DUF3265 domain-containing protein | - |
| BSR23_RS07520 | 1481482..1481982 | + | 501 | WP_077672547.1 | hypothetical protein | - |
| BSR23_RS07525 | 1482024..1482113 | + | 90 | WP_077672554.1 | DUF3265 domain-containing protein | - |
| BSR23_RS07530 | 1482162..1482662 | + | 501 | WP_077672548.1 | hypothetical protein | - |
| BSR23_RS07535 | 1482704..1482793 | + | 90 | WP_072606010.1 | DUF3265 domain-containing protein | - |
| BSR23_RS07540 | 1482826..1483320 | + | 495 | WP_078224678.1 | GNAT family N-acetyltransferase | - |
| BSR23_RS07545 | 1483572..1483985 | + | 414 | WP_078224679.1 | hypothetical protein | - |
| BSR23_RS07550 | 1484743..1484994 | + | 252 | WP_175413455.1 | hypothetical protein | - |
| BSR23_RS07560 | 1485234..1486055 | + | 822 | WP_077673095.1 | HNH endonuclease | - |
| BSR23_RS07565 | 1486073..1486162 | + | 90 | WP_077673101.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD | 1394121..1715920 | 321799 | |
| - | inside | Integron | - | - | 1470987..1572878 | 101891 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11003.69 Da Isoelectric Point: 5.1098
>T138760 WP_015296903.1 NZ_CP043421:1481026-1481313 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV
Download Length: 288 bp
>T138760 NZ_CP058222:2008280-2008534 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10398.91 Da Isoelectric Point: 5.8650
>AT138760 WP_000086647.1 NZ_CP043421:1480748-1481029 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
Download Length: 282 bp
>AT138760 NZ_CP058222:2008032-2008283 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2MSY5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P8G0X0 |