Detailed information of TA system TA138758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1548102..1548781
• Replicon: chromosome
• Accession: NZ_CP043419
• Organism: Acinetobacter baumannii strain 11A1213CRGN064

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FZN68_RS07385
• Protein ID: WP_000838146.1
• Coordinates: 1548102..1548284 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FZN68_RS07390
• Protein ID: WP_000966688.1
• Coordinates: 1548377..1548781 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN68_RS07340	1543175..1543579	+	405	WP_000247948.1	hypothetical protein	-
FZN68_RS07345	1543551..1543919	+	369	WP_002055488.1	hypothetical protein	-
FZN68_RS07350	1543921..1544319	+	399	WP_001251850.1	hypothetical protein	-
FZN68_RS07355	1544321..1544539	+	219	WP_001277687.1	hypothetical protein	-
FZN68_RS07360	1544633..1544986	+	354	WP_000064599.1	hypothetical protein	-
FZN68_RS07365	1544986..1546221	+	1236	WP_000002422.1	hypothetical protein	-
FZN68_RS07370	1546274..1547191	+	918	WP_000094250.1	hypothetical protein	-
FZN68_RS07375	1547261..1547776	+	516	WP_001185608.1	hypothetical protein	-
FZN68_RS07385	1548102..1548284	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FZN68_RS07390	1548377..1548781	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FZN68_RS07395	1548880..1549056	+	177	WP_014466185.1	hypothetical protein	-
FZN68_RS07400	1549065..1549388	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
FZN68_RS07405	1549420..1550214	+	795	WP_000720608.1	hypothetical protein	-
FZN68_RS07410	1550263..1550502	-	240	WP_000763623.1	Arc family DNA-binding protein	-
FZN68_RS07415	1550625..1550780	+	156	WP_001103649.1	Arc family DNA-binding protein	-
FZN68_RS07420	1550777..1551769	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1516828..1572068	55240

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T138758 WP_000838146.1 NZ_CP043419:1548102-1548284 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T138758 NZ_CP058222:1263396-1263707 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT138758 WP_000966688.1 NZ_CP043419:1548377-1548781 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT138758 NZ_CP058222:1263704-1264123 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6