Detailed information of TA system TA138757

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 452678..453331
• Replicon: chromosome
• Accession: NZ_CP043419
• Organism: Acinetobacter baumannii strain 11A1213CRGN064

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FZN68_RS02215
• Protein ID: WP_000607077.1
• Coordinates: 452942..453331 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: FZN68_RS02210
• Protein ID: WP_001288210.1
• Coordinates: 452678..452935 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN68_RS02190	448194..449201	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
FZN68_RS02195	449220..449597	+	378	WP_001216380.1	50S ribosomal protein L17	-
FZN68_RS02200	449779..451269	+	1491	WP_000415126.1	NAD(P)/FAD-dependent oxidoreductase	-
FZN68_RS02205	451318..452490	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
FZN68_RS02210	452678..452935	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
FZN68_RS02215	452942..453331	+	390	WP_000607077.1	membrane protein	Toxin
FZN68_RS02220	454101..455186	+	1086	WP_000049106.1	hypothetical protein	-
FZN68_RS02225	455264..455830	+	567	WP_000651538.1	rhombosortase	-
FZN68_RS02230	456018..458213	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T138757 WP_000607077.1 NZ_CP043419:452942-453331 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T138757 NZ_CP058222:1047906-1048313 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT138757 WP_001288210.1 NZ_CP043419:452678-452935 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT138757 NZ_CP058222:1047659-1047925 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7