Detailed information of TA system TA138756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1549513..1550192
• Replicon: chromosome
• Accession: NZ_CP043418
• Organism: Acinetobacter baumannii strain 11A1314CRGN089

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FZN67_RS07385
• Protein ID: WP_000838146.1
• Coordinates: 1549513..1549695 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FZN67_RS07390
• Protein ID: WP_000966688.1
• Coordinates: 1549788..1550192 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN67_RS07340	1544586..1544990	+	405	WP_000247948.1	hypothetical protein	-
FZN67_RS07345	1544962..1545330	+	369	WP_002055488.1	hypothetical protein	-
FZN67_RS07350	1545332..1545730	+	399	WP_001251850.1	hypothetical protein	-
FZN67_RS07355	1545732..1545950	+	219	WP_001277687.1	hypothetical protein	-
FZN67_RS07360	1546044..1546397	+	354	WP_000064599.1	hypothetical protein	-
FZN67_RS07365	1546397..1547632	+	1236	WP_000002422.1	hypothetical protein	-
FZN67_RS07370	1547685..1548602	+	918	WP_000094250.1	hypothetical protein	-
FZN67_RS07375	1548672..1549187	+	516	WP_001185608.1	hypothetical protein	-
FZN67_RS07385	1549513..1549695	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FZN67_RS07390	1549788..1550192	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FZN67_RS07395	1550291..1550467	+	177	WP_014466185.1	hypothetical protein	-
FZN67_RS07400	1550476..1550799	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
FZN67_RS07405	1550831..1551625	+	795	WP_000720608.1	hypothetical protein	-
FZN67_RS07410	1551674..1551913	-	240	WP_000763623.1	Arc family DNA-binding protein	-
FZN67_RS07415	1552036..1552191	+	156	WP_001103649.1	Arc family DNA-binding protein	-
FZN67_RS07420	1552188..1553180	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1516875..1577377	60502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T138756 WP_000838146.1 NZ_CP043418:1549513-1549695 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T138756 NZ_CP058222:c878398-878021 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT138756 WP_000966688.1 NZ_CP043418:1549788-1550192 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT138756 NZ_CP058222:c878855-878475 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6