Detailed information of TA system TA138741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4266405..4266955
• Replicon: chromosome
• Accession: NZ_CP043414
• Organism: Escherichia coli strain EC42405

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: FZN31_RS20240
• Protein ID: WP_105277274.1
• Coordinates: 4266405..4266719 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: V0VEX8
• Locus tag: FZN31_RS20245
• Protein ID: WP_000125566.1
• Coordinates: 4266722..4266955 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN31_RS20215	4262080..4263366	+	1287	WP_000800457.1	peptidylprolyl isomerase SurA	-
FZN31_RS20220	4263366..4264355	+	990	WP_105288079.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
FZN31_RS20225	4264352..4265173	+	822	WP_001065381.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
FZN31_RS20230	4265176..4265553	+	378	WP_000610901.1	Co2+/Mg2+ efflux protein ApaG	-
FZN31_RS20235	4265560..4266408	+	849	WP_000257193.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH	-
FZN31_RS20240	4266405..4266719	-	315	WP_105277274.1	CcdB family protein	Toxin
FZN31_RS20245	4266722..4266955	-	234	WP_000125566.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FZN31_RS20250	4267041..4267520	-	480	WP_000624375.1	type 3 dihydrofolate reductase	-
FZN31_RS20255	4267713..4269575	-	1863	WP_105267144.1	glutathione-regulated potassium-efflux system protein KefC	-
FZN31_RS20260	4269568..4270098	-	531	WP_000600701.1	glutathione-regulated potassium-efflux system oxidoreductase KefF	-
FZN31_RS20265	4270202..4270435	-	234	WP_032183186.1	YgdI/YgdR family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (8-77)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11708.67 Da
• Isoelectric Point: 8.0665

>T138741 WP_105277274.1 NZ_CP043414:c4266719-4266405 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKDYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Nucleotide

• Length: 315 bp

>T138741 NZ_CP058220:2180707-2180809 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8530.53 Da
• Isoelectric Point: 5.8062

>AT138741 WP_000125566.1 NZ_CP043414:c4266955-4266722 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Nucleotide

• Length: 234 bp

>AT138741 NZ_CP058220:c2180847-2180579 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A7U9LTM9