138739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3847318..3848155 Replicon chromosome
Accession NZ_CP043414
Organism Escherichia coli strain EC42405

Toxin (Protein)


Gene name itaT Uniprot ID V0SED1
Locus tag FZN31_RS18365 Protein ID WP_000227787.1
Coordinates 3847613..3848155 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag FZN31_RS18360 Protein ID WP_001353405.1
Coordinates 3847318..3847629 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZN31_RS18335 3842338..3843285 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
FZN31_RS18340 3843307..3845298 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
FZN31_RS18345 3845288..3845902 + 615 WP_000179807.1 cytochrome o ubiquinol oxidase subunit III -
FZN31_RS18350 3845902..3846231 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
FZN31_RS18355 3846243..3847133 + 891 WP_000971336.1 heme o synthase -
FZN31_RS18360 3847318..3847629 + 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
FZN31_RS18365 3847613..3848155 + 543 WP_000227787.1 GNAT family N-acetyltransferase Toxin
FZN31_RS18370 3848211..3849146 - 936 WP_105287991.1 sel1 repeat family protein -
FZN31_RS18375 3849563..3850927 + 1365 WP_039020794.1 MFS transporter -
FZN31_RS18380 3851055..3851546 - 492 WP_001138904.1 nucleotide binding protein YajQ -
FZN31_RS18385 3851714..3852625 + 912 WP_105287990.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19946.24 Da        Isoelectric Point: 8.8951

>T138739 WP_000227787.1 NZ_CP043414:3847613-3848155 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T138739 NZ_CP058220:1904264-1904518 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT138739 WP_001353405.1 NZ_CP043414:3847318-3847629 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT138739 NZ_CP043414:3847318-3847629 [Escherichia coli]
ATGCCTGGAAAAACAGTCGCTCTACCCGATATCGATAAAACGCTGAAAAATGCGCGGGTTGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCAGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GE43

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References