Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 70740..71572 Replicon chromosome
Accession NZ_CP043414
Organism Escherichia coli strain EC42405

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VCF5
Locus tag FZN31_RS00305 Protein ID WP_000854681.1
Coordinates 70740..71117 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3Z9KHH3
Locus tag FZN31_RS00310 Protein ID WP_021562928.1
Coordinates 71207..71572 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZN31_RS00275 66378..67301 - 924 WP_000535948.1 carboxylate/amino acid/amine transporter -
FZN31_RS00280 67412..68596 - 1185 WP_088541991.1 sugar efflux transporter -
FZN31_RS00285 68995..69156 - 162 Protein_56 virulence RhuM family protein -
FZN31_RS00290 69394..70236 - 843 WP_001280503.1 DUF4942 domain-containing protein -
FZN31_RS00295 70321..70518 - 198 WP_023563519.1 DUF957 domain-containing protein -
FZN31_RS00300 70594..70743 - 150 Protein_59 hypothetical protein -
FZN31_RS00305 70740..71117 - 378 WP_000854681.1 TA system toxin CbtA family protein Toxin
FZN31_RS00310 71207..71572 - 366 WP_021562928.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FZN31_RS00315 71651..71872 - 222 WP_000692300.1 DUF987 domain-containing protein -
FZN31_RS00320 71935..72411 - 477 WP_001186171.1 RadC family protein -
FZN31_RS00325 72426..72911 - 486 WP_000206666.1 antirestriction protein -
FZN31_RS00330 73003..73821 - 819 WP_001175163.1 DUF945 domain-containing protein -
FZN31_RS00335 73911..74144 - 234 WP_001278287.1 DUF905 family protein -
FZN31_RS00340 74150..74827 - 678 WP_001097301.1 hypothetical protein -
FZN31_RS00345 74975..75655 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13963.89 Da        Isoelectric Point: 7.4348

>T138715 WP_000854681.1 NZ_CP043414:c71117-70740 [Escherichia coli]
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T138715 NZ_CP058217:1905213-1905464 [Escherichia coli Nissle 1917]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13528.32 Da        Isoelectric Point: 6.4648

>AT138715 WP_021562928.1 NZ_CP043414:c71572-71207 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT

Download         Length: 366 bp

>AT138715 NZ_CP058217:1905461-1905715 [Escherichia coli Nissle 1917]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VCF5

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z9KHH3

References