Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1486825..1487530 Replicon chromosome
Accession NZ_CP043406
Organism Escherichia coli strain NMBU-W13E19

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag FZN32_RS07550 Protein ID WP_000539521.1
Coordinates 1486825..1487211 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FZN32_RS07555 Protein ID WP_001280945.1
Coordinates 1487201..1487530 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZN32_RS07530 1482829..1483455 + 627 WP_001295292.1 glutathione S-transferase GstB -
FZN32_RS07535 1483452..1484567 - 1116 WP_000555038.1 aldose sugar dehydrogenase YliI -
FZN32_RS07540 1484678..1485061 - 384 WP_000497137.1 biofilm formation regulator BssR -
FZN32_RS07545 1485274..1486599 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
FZN32_RS07550 1486825..1487211 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FZN32_RS07555 1487201..1487530 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
FZN32_RS07560 1487600..1488928 - 1329 WP_000086879.1 GGDEF domain-containing protein -
FZN32_RS07565 1488936..1491284 - 2349 WP_001322378.1 EAL domain-containing protein -
FZN32_RS07570 1491462..1492373 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T138683 WP_000539521.1 NZ_CP043406:1486825-1487211 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T138683 NZ_CP058209:c563644-562322 [Escherichia marmotae]
ATGCCAAAACTTGTCACGTGGATGAACAACCAGCGGGTAGGCGAGTTGACGAAGCTGACCAACGGTGCCCATACCTTTAA
GTATGCGCCGGAGTGGTTGACCAACCGTTATGCCAGGCCATTGTCGCTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGCGACCGCATCGTTAAACGTTATCAT
GCTAAATCCAGGCAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGCGCCGTGACGTTATTACCAGAAGA
CGAAACCGTGACGCGCCCAATAATGGTATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGGGAGGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACTGCGCTG
CTCAGAATGGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCATATCATTAAATTGCCGATTGGTGAAAT
CAGACAGCCCAATGCGACGCTCGATCTCAGTCAGAGTGTTGATAATGAGTATTACTGTCTGCTGCTGGCAAAAGAATTCG
GGTTGAATGTTCCCGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGCTTTGACAGGCGCTGG
AATACTGAACGAACGGTTTTACTTCGCTTGCCGCAGGAGGATATGTGTCAGACGTTCGGTTTACCTTCATCGGTGAAATA
TGAATCTGACGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTATTCCAGTGGTTGATTGGCTCGACAGACGGCCATGCGAAAAATTTCTCAGTGTTTATCCAG
GCCGGTGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCGGGAATACATAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAGAAAAACGGAAATCGATAAAATATATCCGCGACATT
TTTTGGCGACAGCAAAGGCACTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCC
GCAGCATTGGATAACGTGAAGGCTTCATTACCGGCAGATTTTCCGGAGAACGTGTTGACGGCAATTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATATGGAATTAAGTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT138683 WP_001280945.1 NZ_CP043406:1487201-1487530 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT138683 NZ_CP043406:1487201-1487530 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References