Detailed information of TA system TA138679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 694219..695807
• Replicon: chromosome
• Accession: NZ_CP043406
• Organism: Escherichia coli strain NMBU-W13E19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U9YVT8
• Locus tag: FZN32_RS03500
• Protein ID: WP_001125415.1
• Coordinates: 694485..695807 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FZN32_RS03495
• Protein ID: WP_001296726.1
• Coordinates: 694219..694485 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN32_RS03495	694219..694485	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
FZN32_RS03500	694485..695807	+	1323	WP_001125415.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
FZN32_RS03505	696205..696846	-	642	WP_173002387.1	LysR family transcriptional regulator	-
FZN32_RS03510	696986..697294	+	309	WP_001221046.1	hypothetical protein	-
FZN32_RS03515	697303..697992	+	690	WP_000801313.1	type 1 glutamine amidotransferase domain-containing protein	-
FZN32_RS03520	698066..699013	+	948	WP_000854796.1	aldo/keto reductase	-
FZN32_RS03525	699116..699271	+	156	WP_001322415.1	hypothetical protein	-
FZN32_RS03530	699231..699650	+	420	WP_001322416.1	amidohydrolase family protein	-
FZN32_RS03535	699601..699792	+	192	WP_001469139.1	amidohydrolase family protein	-
FZN32_RS03540	699943..700515	+	573	WP_000789913.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49384.05 Da
• Isoelectric Point: 8.5830

>T138679 WP_001125415.1 NZ_CP043406:694485-695807 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Nucleotide

• Length: 1323 bp

>T138679 NZ_CP058207:c3735708-3735220 [Escherichia marmotae]
ATGATCTCCGCTCCTGAGCCGCTTCACGCCGGGCATATTCTTACCCCATTTTGCTGTGGCGTGGATTCTATGGATAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGTACTTTTGTATGTTGCGGCAGTGATTCTAAGGTAC
TGGCGTATTACTCGCTGGCATCCAGTGCAGTGATGACAAACACTGCCCCCGGCCGCTTTCGCCGTAATATGCCCGATCCG
ATCCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATCAGTCTATACATGGGCAGGGTGTTGGTCGGGCGCTGGTACGTGA
CGCCGGGCTGCGGGTGATTCAGGTGGCTGAAACTATCGGTATTCGCGGGATGCTGGTTCATGCGCTGTCTGATGAGGCGC
GGGATTTCTATCTGCGGGTGGGGTTTGAGCCGTCACCGATGGATCCGATGATGTTGCTGGTGACGTTGGGGGATTTGGTT
CATGCTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT138679 WP_001296726.1 NZ_CP043406:694219-694485 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT138679 NZ_CP058207:c3735998-3735705 [Escherichia marmotae]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAATCTGCGCATCAGGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCGAAAGCCAGAGGAAAAAACCGCACTGACTTTGTGCTGGAGGCTGCCCGCGCCGCGGCGGAAGAGGCGCTGA
TCGAGCAGCGTATCATTATGGCCGATCCGGAGGCTTATCAGACGTTTCTTACCCGCCTTGATCAGGCTCCAGCGCCAAAC
TCCGCGCTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: U9YVT8