Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2077946..2078497 Replicon chromosome
Accession NZ_CP043405
Organism Streptococcus ratti strain ATCC 31377

Toxin (Protein)


Gene name relE Uniprot ID J3A254
Locus tag FY406_RS10285 Protein ID WP_003088886.1
Coordinates 2078219..2078497 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J3JPN4
Locus tag FY406_RS10280 Protein ID WP_003088883.1
Coordinates 2077946..2078218 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY406_RS10275 2074111..2077356 - 3246 WP_003088881.1 ATP-dependent nuclease subunit B -
FY406_RS10280 2077946..2078218 + 273 WP_003088883.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FY406_RS10285 2078219..2078497 + 279 WP_003088886.1 type II toxin-antitoxin system YafQ family toxin Toxin
FY406_RS10290 2078646..2080304 - 1659 Protein_1970 hypothetical protein -
FY406_RS10295 2081550..2082452 - 903 WP_003088894.1 type I-E CRISPR-associated endoribonuclease Cas2 -
FY406_RS10300 2082454..2083395 - 942 WP_003088896.1 type I-E CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 8.0690

>T138668 WP_003088886.1 NZ_CP043405:2078219-2078497 [Streptococcus ratti]
MYQVKFTSAFKKSFKRMKKRGMDVSLLDDVIEKLHLGQALEDRYRDHELKGSFKGFRECHIKPDWLLIYLLEDDILTLTL
VDTGSHADLFKM

Download         Length: 279 bp

>T138668 NZ_CP058207:394040-394213 [Escherichia marmotae]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTCTCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGCCTGCCCGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9954.35 Da        Isoelectric Point: 4.5368

>AT138668 WP_003088883.1 NZ_CP043405:2077946-2078218 [Streptococcus ratti]
MATVPTQIRIDETVKAQATSLFNDLGIDMSSAVNIFLRQCLLHDGLPFNVELPNYNSKTLEAMAEAKRISHDEAVVAYDN
MSDLKKALEA

Download         Length: 273 bp

>AT138668 NZ_CP058207:393717-394013 [Escherichia marmotae]
ATGGAAGGTATAAACAGGTTCAAAACTTACGTTGTTTCTTTTGATTATCCATCATCTTATTACTCAGTTTTCTTAAGGTT
AAGGTCGTTAATGTATGATATGGATTTCTCCTCTATAGTTGCTGATGAATATGGAATACCACGACAATTGAATGAGAATG
CTTTCGCAATAACGACATCATTAGCCGCAAGTGAAATTGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCAGATATT
GATTTTGACCTCAACATTATGATAGTCGATGACTATTTCCGTCAGTTCTACAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X9QH77

Antitoxin

Source ID Structure
AlphaFold DB J3JPN4

References