Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1977338..1977924 Replicon chromosome
Accession NZ_CP043405
Organism Streptococcus ratti strain ATCC 31377

Toxin (Protein)


Gene name hicA Uniprot ID J3FA25
Locus tag FY406_RS09830 Protein ID WP_003088683.1
Coordinates 1977718..1977924 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID J3JPS8
Locus tag FY406_RS09825 Protein ID WP_003088681.1
Coordinates 1977338..1977715 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY406_RS09810 1972754..1974541 - 1788 WP_003088674.1 LPXTG cell wall anchor domain-containing protein -
FY406_RS09815 1974706..1974969 - 264 WP_003088676.1 helix-turn-helix transcriptional regulator -
FY406_RS09820 1975294..1976187 + 894 WP_003088678.1 XRE family transcriptional regulator -
FY406_RS09825 1977338..1977715 - 378 WP_003088681.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FY406_RS09830 1977718..1977924 - 207 WP_003088683.1 type II toxin-antitoxin system HicA family toxin Toxin
FY406_RS09835 1978023..1978685 - 663 WP_003088686.1 type II-A CRISPR-associated protein Csn2 -
FY406_RS09840 1978675..1979019 - 345 WP_003088688.1 CRISPR-associated endonuclease Cas2 -
FY406_RS09845 1979016..1979885 - 870 WP_003088691.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7693.11 Da        Isoelectric Point: 11.0638

>T138667 WP_003088683.1 NZ_CP043405:c1977924-1977718 [Streptococcus ratti]
MPLTGKELARLAVKNGWEEVRVRGSHHHFKKNGVSCIVTIPIHGNQSLKVGLEKKILKDLGLLEQRRK

Download         Length: 207 bp

>T138667 NZ_CP043405:c1977924-1977718 [Streptococcus ratti]
TTGCCCTTGACTGGCAAAGAATTAGCCAGGTTGGCTGTAAAAAATGGATGGGAAGAAGTTCGGGTGAGAGGGAGTCATCA
TCATTTTAAGAAAAATGGAGTGTCTTGTATCGTAACGATTCCGATTCATGGTAATCAATCACTTAAAGTTGGTCTTGAAA
AGAAAATCTTGAAGGATTTAGGGCTGCTAGAACAGAGGAGGAAGTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14280.33 Da        Isoelectric Point: 4.9845

>AT138667 WP_003088681.1 NZ_CP043405:c1977715-1977338 [Streptococcus ratti]
MLKSYPAIFHKEKKGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPSPSDIREVSVDDGFVTMIQADP
SPYLRNNKAIRKNVTVPEWLVRLADRDQVNYSEVLTKALEKKLQL

Download         Length: 378 bp

>AT138667 NZ_CP058201:4377-107 [Enterobacter roggenkampii]

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J3FA25

Antitoxin

Source ID Structure
AlphaFold DB J3JPS8

References