Detailed information of TA system TA138665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 727052..728012
• Replicon: chromosome
• Accession: NZ_CP043405
• Organism: Streptococcus ratti strain ATCC 31377

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: J2ZZI9
• Locus tag: FY406_RS03605
• Protein ID: WP_003090352.1
• Coordinates: 727052..727576 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: J3JNL8
• Locus tag: FY406_RS03610
• Protein ID: WP_003090345.1
• Coordinates: 727566..728012 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY406_RS03575	722997..723395	+	399	WP_003090364.1	Mini-ribonuclease 3	-
FY406_RS03580	723484..723675	+	192	Protein_661	metallopeptidase	-
FY406_RS03585	723722..724357	-	636	WP_003090360.1	GyrI-like domain-containing protein	-
FY406_RS03590	724359..724877	-	519	WP_003090358.1	PadR family transcriptional regulator	-
FY406_RS03595	724995..725747	+	753	WP_174267045.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
FY406_RS03600	725771..726631	+	861	WP_003090353.1	DegV family protein	-
FY406_RS03605	727052..727576	+	525	WP_003090352.1	hypothetical protein	Toxin
FY406_RS03610	727566..728012	+	447	WP_003090345.1	hypothetical protein	Antitoxin
FY406_RS03615	728009..728203	+	195	WP_003090343.1	helix-turn-helix transcriptional regulator	-
FY406_RS03620	728510..728956	+	447	WP_003090341.1	50S ribosomal protein L13	-
FY406_RS03625	728979..729371	+	393	WP_150880988.1	30S ribosomal protein S9	-
FY406_RS03630	729630..730166	+	537	WP_003090337.1	SdpI family protein	-
FY406_RS03635	730331..730927	+	597	WP_003090335.1	ATP-binding protein	-
FY406_RS03640	731060..733009	-	1950	WP_003090334.1	BglG family transcription antiterminator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 20213.84 Da
• Isoelectric Point: 7.9744

>T138665 WP_003090352.1 NZ_CP043405:727052-727576 [Streptococcus ratti]
MFDFVMNLILLAIAVGVFVFLRFYADEKGRREYDERQLLMQKKAYTNAAWVVMAFNFILAMWGDELGQYITLAFAGMASL
FLIVGVFVCSSILNDAYFTAKKSKRFLYLYVIMITIQMFIVYKNWNQGRFSHDGHLYLTGDNSMSLLFIITFAVILLVSA
YKMMQDKRENADEN

Nucleotide

• Length: 525 bp

>T138665 NZ_CP058198:c76380-75964 [Enterobacter roggenkampii]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16812.01 Da
• Isoelectric Point: 9.9630

>AT138665 WP_003090345.1 NZ_CP043405:727566-728012 [Streptococcus ratti]
MKIEKSKQEVIYDERQQQIQLKSYALSFWFVMAILYIATLGKPNLLLNIAFWGGLTLNVCYSTLKGASLFVDQRFGKFAK
IGRWIGLPVMLLGAGVLIITVIVGFVKHTTLKEFLDMGSFLWVSALSLICMGASIFYRNYRNKKEADE

Nucleotide

• Length: 447 bp

>AT138665 NZ_CP058198:c76607-76377 [Enterobacter roggenkampii]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: J2ZZI9

Antitoxin

• AlphaFold DB: J3JNL8