Detailed information of TA system TA138664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 526414..526985
• Replicon: chromosome
• Accession: NZ_CP043405
• Organism: Streptococcus ratti strain ATCC 31377

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: J3FB23
• Locus tag: FY406_RS02455
• Protein ID: WP_003089972.1
• Coordinates: 526414..526746 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: J3AL72
• Locus tag: FY406_RS02460
• Protein ID: WP_003089974.1
• Coordinates: 526740..526985 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY406_RS02425	521634..523481	+	1848	WP_003089963.1	APC family permease	-
FY406_RS02430	523713..524825	-	1113	WP_003089965.1	vitamin B12 independent methionine synthase	-
FY406_RS02435	525080..525262	+	183	WP_003079131.1	50S ribosomal protein L32	-
FY406_RS02440	525278..525427	+	150	WP_002262412.1	50S ribosomal protein L33	-
FY406_RS02445	525662..526027	+	366	WP_003089968.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FY406_RS02450	526014..526289	+	276	WP_003089969.1	helix-turn-helix domain-containing protein	-
FY406_RS02455	526414..526746	-	333	WP_003089972.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FY406_RS02460	526740..526985	-	246	WP_003089974.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FY406_RS02465	527050..527334	-	285	WP_003089975.1	hypothetical protein	-
FY406_RS02470	527647..528546	-	900	WP_003089978.1	LysR family transcriptional regulator	-
FY406_RS02475	528674..529027	-	354	WP_037611279.1	helix-turn-helix transcriptional regulator	-
FY406_RS02480	529189..529794	+	606	WP_003089981.1	DUF1269 domain-containing protein	-
FY406_RS02485	529855..531048	+	1194	WP_003089982.1	oxalate decarboxylase family bicupin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-107)

Antitoxin

• SpoVT-AbrB domain (7-47)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12536.56 Da
• Isoelectric Point: 9.5537

>T138664 WP_003089972.1 NZ_CP043405:c526746-526414 [Streptococcus ratti]
MVSIKQGSIIKINLNPKQGHEQKGYRPYICLSHSVVTKYSNLAIFAPISNTKRDYPFYVPLKDTETTGKVLLDQLVTIDF
NARDYRYIEDVSGELLISLLARVKVLFEKG

Nucleotide

• Length: 333 bp

>T138664 NZ_CP058198:c74649-74338 [Enterobacter roggenkampii]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9218.49 Da
• Isoelectric Point: 4.6286

>AT138664 WP_003089974.1 NZ_CP043405:c526985-526740 [Streptococcus ratti]
MQLTVNKWGNSSAIRLPKQLVQQLQLHTNDILDYEVSGNKIILKKATTVPELTVDDLFKDYQGEPVSVTPFIFESVGNEQ
W

Nucleotide

• Length: 246 bp

>AT138664 NZ_CP058198:c74341-73922 [Enterobacter roggenkampii]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Structures

Toxin

• AlphaFold DB: J3FB23

Antitoxin

• AlphaFold DB: A0A2X3W467