138663

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1019171..1019807 Replicon chromosome
Accession NZ_CP043404
Organism Bacillus safensis strain PgKB20

Toxin (Protein)


Gene name mazF Uniprot ID A0A0P7G713
Locus tag FX981_RS05170 Protein ID WP_024425388.1
Coordinates 1019171..1019521 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag FX981_RS05175 Protein ID WP_003214273.1
Coordinates 1019526..1019807 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX981_RS05130 1014202..1014801 - 600 WP_024425395.1 SpoIIE family protein phosphatase -
FX981_RS05135 1014801..1015589 - 789 WP_024427378.1 RNA polymerase sigma factor SigB -
FX981_RS05140 1015555..1016043 - 489 WP_024425393.1 anti-sigma B factor RsbW -
FX981_RS05145 1016040..1016369 - 330 WP_024425392.1 anti-sigma factor antagonist -
FX981_RS05150 1016429..1017436 - 1008 WP_024425391.1 PP2C family protein-serine/threonine phosphatase -
FX981_RS05155 1017447..1017848 - 402 WP_024425390.1 anti-sigma regulatory factor -
FX981_RS05160 1017851..1018219 - 369 WP_003214235.1 RsbT antagonist protein RsbS -
FX981_RS05165 1018224..1019054 - 831 WP_044334717.1 RsbT co-antagonist protein RsbRA -
FX981_RS05170 1019171..1019521 - 351 WP_024425388.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FX981_RS05175 1019526..1019807 - 282 WP_003214273.1 hypothetical protein Antitoxin
FX981_RS05180 1020102..1021283 - 1182 WP_149125955.1 alanine racemase -
FX981_RS05185 1021425..1022441 - 1017 WP_087975235.1 outer membrane lipoprotein carrier protein LolA -
FX981_RS05190 1022602..1022967 - 366 WP_024425385.1 holo-ACP synthase -
FX981_RS05195 1023062..1023667 + 606 WP_024425384.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8891

>T138663 WP_024425388.1 NZ_CP043404:c1019521-1019171 [Bacillus safensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T138663 NZ_CP058198:c72580-72110 [Enterobacter roggenkampii]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT138663 WP_003214273.1 NZ_CP043404:c1019807-1019526 [Bacillus safensis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT138663 NZ_CP043404:c1019807-1019526 [Bacillus safensis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P7G713

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References